少节点基因调控网络的控制  

Control of few node genetic regulatory networks

作　　者：叶纬明[1] 吕彬彬[2] 赵琛[1] 狄增如[1] 

机构地区：[1]北京师范大学管理学院系统科学系,北京100875 [2]北京有色金属研究总院稀土材料国家工程研究中心,有研稀土新材料股份有限公司,北京100088

出　　处：《物理学报》2013年第1期72-77,共6页Acta Physica Sinica

基　　金：国家自然科学基金(批准号:11174034)资助的课题~~

摘　　要：近年来,自组织振荡网络受到越来越多科学家的关注,对生物体的生长、发育起调控作用的基因调控网络即是其中的一种.本文研究了少节点基因调控网络的控制问题.运用多相位超前驱动方法对该种网络进行调控,可以有效地提高对网络的控制效率.通过数值模拟,发现对于少节点基因调控网络,当系统参数确定时,网络的有效控制率可以达到95%以上(10节点网络);当系统参数不确定时,控制的效率也非常高.Recently, self-organized oscillation networks have aroused great interest in diverse natural and social fields. Genetic regulatory networks are one of the most typical examples of this kind. They control the growth and develop of organism. We investigate the control of few node genetic regulatory networks. We use a method of multiple phase advanced driving to control the networks, which can improve the control efficiency. The numerical simulation, results show that for the network in which system parameter is fixed, the control efficiency will reach 95% （for 10-node network）, and the method will also applicable for the network in which system parameter is unfixed.

关 键 词：基因调控网络 负反馈环 振荡模体 

分 类 号：Q75[生物学—分子生物学]