甾体类药物治疗子宫内膜异位症效果观察  

The observation of the effect for steroidal anti-drug in the treatment of endometriosis

作　　者：雷德英 

机构地区：[1]四川省乐至县中医医院妇产科,四川乐至641500

出　　处：《实用中医药杂志》2013年第1期44-45,共2页Journal of Practical Traditional Chinese Medicine

摘　　要：目的:观察甾体类药物米非司酮治疗子宫内膜异位症的疗效。方法:92例子宫内膜异位症患者,均行开腹手术剔除异位囊肿,术后随机分为两组。观察组46例给予米非司酮治疗,对照组46例给予孕三烯酮治疗,疗程均为6个月,随访6～24个月,观察两组患者治疗前后症状、体征、妊娠率及不良反应。结果:观察组治愈31例,有效12例,无效3例,复发3例,总有效率93.48%,复发率6.52%。对照组治愈31例,有效13例,复发2例,无效2例,总有效率95.65%,复发率4.35%。两组总有效率比较无显著性差异,(P>0.05)。观察组不良反应9例(19.57%),不良反应分别为阴道不规则出血、转氨酶升高;对照组发生不良反应46例(100%),不良反应除阴道不规则出血、转氨酶升高外,主要为雄性激素作用产生的体重、体毛增加及痤疮。两组不良反应发生率比较具有显著性差异,(P<0.05)。结论:甾体类药物米非司酮是治疗子宫内膜异位症较理想药物,使用后,可使子宫内膜萎缩,在确保治疗效果、缓解症状的同时不良反应少,可作为治疗子宫内膜异位症的首选药物。Objective ： To observe the efficacy of steroidal drug mifepristone in the treatment of endometriosis.Method ： 92 cases of endometriosis patients from March 2009 to March 2010 were chosen as the research object.All patients were with laparoscopic surgery.They were randomly divided into two groups, the observation group of 46 patients was given steroids mifepristone treatment, and the control group of 46 cases was treated with gestrinone treatment.The course was of 6 months, all patients were followed up for 6 - 24 months, and the symptoms, signs, pregnancy rate and side effects for the two groups of patients before and after treatment were observed.Results： There were 31 cases cured, 12 cases was effective in the observation group, the total efficiency rate was 93.48%.The invalid and recurrence was in three cases, the recurrence rate was 6.52%.There were 31 cases cured, 13 cases effective in the control group, and the total efficiency rate was 95.65%.The relapse and ineffective was in two cases, the recurrence rate was 4.35%, there was no significant difference between the two groups, and there was not statistically significant, P 〉 0.05.There were nine cases of adverse reactions in the observation group, and the incidence rate was 19.57%.The adverse effects were of irregular bleeding , transaminaseincreased.Theadverse reactions in the control group was 46 cases, the incidence of adverse reactions was 100%.In addition to irregular bleeding, elevated aminotransferases the role of the male hormone, body weight, body hair and acne, the difference was significant, there was statistically significant P 〈 0.05.Conclusion： The steroidal drug mifepristone is the better drug for the treatment of endometriosis.After treatment for the patents, the endometrial is shriveled.At the time of ensuring the treatment effect, alleviating the side effects, the clinical symptoms significantly reduced.It can be used as the first choice for the treatment of endometriosis.

关 键 词：甾体类药物 米非司酮 子宫内膜异位症 

分 类 号：R711.71[医药卫生—妇产科学]