持续气道正压通气对阻塞性睡眠呼吸暂停综合征患者勃起功能障碍疗效的meta分析  

Effect of continuous positive airway pressure on erectile dysfunction in patients with obstructive sleep apnea syndrome:A meta-analysis

作　　者：徐健[1] 黄平[1] 宋冰[1] 陈济明[1] 

机构地区：[1]广东医学院附属南山医院呼吸内科,广东深圳518052

出　　处：《中华男科学杂志》2013年第1期77-81,共5页National Journal of Andrology

摘　　要：目的:评价持续气道正压通气(CPAP)对阻塞性睡眠呼吸暂停综合征(OSAS)患者勃起功能障碍(ED)的影响。方法:计算机检索Cochrane Library、PubMed、中国学术期刊全文数据库、中国生物医学文献数据库、万方资源数据库和中国重要会议论文全文数据库并手工检索相关期刊,全面收集CPAP对OSAS合并性功能障碍的临床研究,按照纳入、排除标准选择实验研究并评价质量,而后提取有效数据进行meta分析。结果:最终纳入4篇文献,1篇中文,3篇英文,包括77例患者。meta分析结果显示各研究间无统计学异质性(P=0.80;I2=0%),故采用固定效应模型进行meta分析。结果显示经CPAP治疗后,IIEF-5增高[WMD=4.19,95%(3.01,5.36),P<0.001]。结论:现有临床研究证据显示,对于OSAS合并ED患者,CPAP治疗能明显减轻ED。但因研究质量及研究样本存在明显局限性,期待更多高质量、大规模的临床随机对照研究加以验证。[ Abstract] Objective： To evaluate the effect of continuous positive airway pressure （CPAP） on erectile dysfunction （ED） in patients with obstructive sleep apnea syndrome （OSAS）. Methods： We searched Cochrane Library, PnbMed, China Academic Jour- nal Full-Text Database, Chinese Biomedical Literature Database, Wanfang Resource Database and Chinese Journal Full-Text Database for clinical trials on the effect of CPAP on ED in OSAS patients. We identified the trials according to inclusion and exclusion criteria, evaluated their quality, and then extracted valid data for meta-analysis. Results ： We included 4 articles, 3 in English and 1 in Chi- nese, involving 77 cases of OSAS with ED. Meta-analysis revealed no statistically significant heterogeneity among different studies （P = O. 80 ; 12 = 0% ）, and therefore the fixed effect model was used for the analysis, which showed a significant increase in the IIEF-5 score after CPAP treatment （ WMD = 4.19, 95% [ 3.01,5.36 ], P 〈 0. 001 ）. Conclusion ： The existing evidence from clinical tri- als shows that the CPAP therapy can significantly improve ED in OSAS patients. However, its efficacy has to be verified by randomized controlled clinical trials of higher quality and larger sample size.

关 键 词：阻塞性睡眠呼吸暂停综合征 勃起功能障碍 持续气道正压通气 系统评价 META分析 

分 类 号：R698.1[医药卫生—泌尿科学]