双环醇对肝切除术后急性肝损伤患者保护作用的随机对照研究  

Protective effect of bicyclol on liver function in patients after liver resection： a randomized control trial

作　　者：陆炯炯[1] 张敏峰[1] 施长鹰[1] 杨甲梅[1] 

机构地区：[1]第二军医大学东方肝胆外科医院,上海200438

出　　处：《中华肝胆外科杂志》2013年第1期19-22,共4页Chinese Journal of Hepatobiliary Surgery

摘　　要：目的 探讨双环醇对肝切除术后急性肝损伤患者的保护作用.方法 肝切除术病例120例,随机分成三组,每组40例.A组术前5d口服双环醇片,50mg/次,每日3次.B组术前5d口服甘草酸二铵,150 mg/次,每日3次.C组术前5d口服水飞蓟片,77 mg/次,每日3次.三组均口服药物5d后,在入肝血流阻断下行肝切除术.术后第3天至7天各组继续口服上述药物,剂量同前.分别于术前以及术后第1、3、5、7天抽空腹静脉血检测血清丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、总胆红素（TB）、碱性磷酸酶（ALP）、前白蛋白（PAB）的含量.结果 A组患者术后1、3、5、7d ALT明显低于B组和C组（P＜0.01）.A组术后7dALT复常率明显高于B组及C组（P＜0.05）.结论 肝切除术前后口服双环醇片较口服甘草酸二铵和水飞蓟片有更明显的减缓术后血清ALT急剧升高和促进血清ALT复常的作用.Objective This study investigates the protective effect of bicyclol on liver function in patients after liver resection.Methods One hundred and twenty patients undergoing liver resection with Pringle＇s maneuver were randomly divided into groups A,B,and C,and given bicyclol （50 mg）,diammonium glycyrrhizinate （150 mg）,and silybum marianum （77 mg）,respectively.The medication was orally given preoperatively for 5 days and postoperatively for days 3 to 7.The fasting serum ALT,AST,TB,ALP,and PAB levels were determined before operation and on days 1,3,5,and 7 after operation.Results ALT levels in the A group were significantly lower than those in the B and C group on post operative days 1,3,5,and 7 （P〈0.01）.On postoperative day 7,the ratio of serum ALT returned to normal was significantly higher than the B and C group ratios （P〈0.05）.Conclusion Therefore,oral bicyclol given before and after liver resection can significantly inhibit the rapid increase and promote the normalization of serum ALT levels.

关 键 词：双环醇 肝切除 肝功能 

分 类 号：R657.3[医药卫生—外科学]