^99mTc—GSASPECT显像在肝脏疾病中的应用  

99mTc-GSA SPECT imaging in liver diseases

作　　者：陈静 李建生 许戈良 英卫东 马金良 

机构地区：[1]安徽医科大学附属省立医院普外科肝胆胰外科安徽省重点实验室,合肥230001

出　　处：《中华肝胆外科杂志》2013年第1期75-78,共4页Chinese Journal of Hepatobiliary Surgery

基　　金：国家自然科学基金资助项目（81172364）;安徽高校省级自然科学研究重点项目（KJ2011A171）

摘　　要：去唾液酸糖蛋白受体（ASGPR）是哺乳动物肝细胞表面的特异性受体，能专一摄取血液中的糖蛋白。肝细胞表面AsGPR的数量与肝脏功能状态具有明显的相关性，受体数量减少提示肝功能不全。肝硬化、门脉高压症和肝癌患者的ASGPR数量减少，导致肝脏储备功能下降，极易发生术后并发症。锝标记的半乳糖基人血清白蛋白（^99mTc—GSA）对该受体显像，结合单光子发射型计算机断层显像（SPECT）技术，可用于预测术后剩余肝脏的储备功能和术后并发症的发生，协助临床手术决定。本文就^99mTc—GSASPECT显像在肝脏外科应用的现状和进展进行综述。Asialogycoprotein receptor （ASGPR） is a specific receptor of mammalian hepatocytes, exclusively uptake the glycoprotein in the blood. The number of ASGPR correlates significantly with liver function, and the reduction of the number of ASGPR suggest liver dysfunction. De creased ASGPR in patients with liver cirrhosis or portal hypertension or hepatocellar carcinoma, lead to varying degrees of liver dysfunction, which made it more susceptible to postoperative complications. Liver ASGPR scintigraphy with Technetium 99 m-DTPA-galactosyl human serum albumin （99m Tc-GSA）, combinating with single photon emission computed tomography （SPECT） technology can assess the functional reserve of remnant liver and predict incidence of postoperative complications, then assist to evaluate the use- fulness for clinically surgical decisions. Current situation and progress of 99mTc-GSA SPECT imaging in hepatic surgery were reviewed in the paper.

关 键 词：去唾液酸糖蛋白受体 ^99mTc—DTPA半乳 糖人血清白蛋白 单光子发射型计算机断层显像 肝脏储备功能 

分 类 号：R657.3[医药卫生—外科学]