CA125在肾病综合征患者中的表达  

The expression of CA125 in patient with nephrotic syndrome

作　　者：孙祥龙 刘志启 

机构地区：[1]山东省潍城区经济开发区人民医院,山东省潍坊市261057

出　　处：《临床合理用药杂志》2013年第4期17-18,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的探讨肾病综合征(NS)患者血清CA125水平的变化及其临床意义。方法将96例NS患者分为A组(伴有浆膜腔积液)和B组(无浆膜腔积液)各48例;另选20名健康体检者作为正常对照组(C组)。采用化学发光标记免疫法(CLIA)测定各组血清CA125水平,比较各组治疗前后血清CA125水平及血白蛋白水平,并分析两者间的相关性。结果 A组CA125水平高于B、C组,差异有统计学意义(P<0.05)。96例NS患者治疗后白蛋白水平明显升高,血清CA125水平明显降低,差异均有统计学意义(P<0.05)。血清CA125水平与白蛋白呈负相关(r=-0.401,P=0.008)。结论 NS患者血清CA125水平升高与浆膜腔积液关系密切,且随着NS的治疗好转而逐渐下降。Objective To discuss the change of serum CA125 in patient with nephrotic syndrome（NS） and its clinical significance.Methods 96 cases patients with NS were divided into A group（serosal fluids） and B group（non-serous effusions）,each of 48 cases;Elected 20 cases healthy subjects as a control group（C group）.By chemiluminescent tag immunoassay（CLIA）,determined serum CA125 level,compared serum CA125 level and albumin level before and after treatment and analysised the correlation.Results CA125 level of A group was higher than that of B and C group,the difference were statistically significance（P〈0.05）.In 96 cases patients of NS,after treatment,albumin level was significantly increased,serum CA125 level was significantly lower,the difference were statistically significant（P〈0.05）.Serum CA125 level and albumin were negatively correlated（r=-0.401,P=0.008）.Conclusion Serum CA125 level of NS patient increased with serous effusions are closely related,and with NS treated better and gradually decreased.

关 键 词：肾病综合征 血清CA125 浆膜腔积液 

分 类 号：R692.3[医药卫生—泌尿科学]