慢性阻塞性肺疾病合并肺纤维化的研究进展  

Research progress of chronic obstructive pulmonary disease along with pulmonary fibrosis

作　　者：黄建戈[1] 谢敏[1] 

机构地区：[1]四川大学华西医院呼吸内科,成都610041

出　　处：《国际呼吸杂志》2013年第1期69-74,共6页International Journal of Respiration

摘　　要：慢性阻塞性肺疾病（COPD）是一组以不完全可逆的气流受限为特征的慢性肺疾病，肺纤维化（PF）是机体对炎症修复的反应。在COPD发展过程中，由于长期吸烟及有毒物质和气体的刺激造成气道的反复感染引起慢性炎症的反复发生，这将使气管和肺泡损伤而导致气道的重塑和肺泡的修复，最终促进PF的形成。这使原来临床表现突出的单一性疾病变成非典型性或兼有两种疾病的特点的疾病，为临床诊断和治疗带来了挑战。因此，研究和探索COPD合并PF的发病机制、病理改变，寻求早期预防措施及探讨新的治疗方法具有重要意义。Chronic obstructive pulmonary disease （COPD） is a group with not completely reversible air limited chronic lung disease, and pulmonary fibrosis is the body＇s repair response to inflammation. In the process of the development of COPD, due to long-term smoking toxic substances and gas stimulation, it causes airway and lung repeated infection which causes chronic inflammation of the recurring. This will lead to the airway and alveolar damage, cause the airway remodeling and alveolar repair, and finally promote the formation of pulmonary fibrosis. This makes the Original clinical manifestations of the prominent and monotonous disease to become atypical or with the disease of the characteristics of the disease, which presents new challenges for clinical diagnosis and treatment. Therefore, to study and explore with the pathogenesis of COPD and PF, pathological changes, to seek the preventive measure and to explore a new treatment is of great significance.

关 键 词：肺疾病 阻塞性 肺纤维化 

分 类 号：R563.9[医药卫生—呼吸系统]