CD4^+ T细胞亚群在支气管哮喘病理机制中作用的新认识  

CD4^+ T cells in asthma pathogensis

作　　者：张琳[1] 梁庆红[1] 王烨[1] 

机构地区：[1]河北医科大学第三医院儿科,河北石家庄050051

出　　处：《中国微生态学杂志》2013年第1期100-103,共4页Chinese Journal of Microecology

摘　　要：CD4+T细胞对病原微生物可产生有效免疫应答,依据其产生细胞因子不同分为辅助I型T细胞(Th1)和辅助II型T细胞(Th2),目前其他亚型已被鉴定,包括Th17、调节性T细胞(Treg),滤泡型T细胞和Th9细胞等。调节性T细胞既抑制Th1,也抑制Th2发育。最近研究报道,在过敏性疾病和哮喘患者中Treg细胞数量减少,并认为是通过下调Th1和Th2细胞以外的其他亚类细胞而抑制过敏和哮喘发作的。在这篇综述中,我们将进一步探讨Th1、Th2、Th17、Th9以及Treg在过敏性和哮喘疾病中的作用。CD4＋T cells are regulated effective immune response to pathogens,Na？ve CD4＋ T cells are active after interaction with antigen——MHC complex and differentiate into specific subtypes depending mainly on the cytoking milieu of the microenvironment.Basides the classical T-helper 1 and T-helper 2,other subsets have been identified,including T-helper 17,regulatory T cell,follicular help T cell,and T help-9,each with a characteristic cytoking profile.Regulatory T（Treg） cells are considered to inhibit the development of both type 1（Th1） and type 2 helper T（Th2） cells.It is recently reported that there are reduced numbers of Treg cells in patients with allergic diseases and asthma.Therefore,Treg cells may suppress the onset of allergic disease and asthma by down-regulating other types of immune cells besides Th1 and Th2 cells.The newly discovered interleukin 17 producing helper T cells that are responsible for autoimmune inflammatory diseases may counteract Treg cells even in allergic diseases and asthma.In this review,we further discuss the role of Th1,Th2,Th17,Th9 and Treg cells in allergic diseases and asthma.

关 键 词：支气管哮喘 TH1 TH2细胞亚群 Treg Th17细胞亚群 TH9细胞 Th25细胞 INKT细胞 

分 类 号：R562.25[医药卫生—呼吸系统]