耐碳青霉烯类鲍曼不动杆菌产OXA酶的研究进展  

Research advances of oxaclillinase in carbapenem-resistant Acinetobacter baumannii

作　　者：钟敏[1] 黄文芳[1] 

机构地区：[1]四川省医学科学院.四川省人民医院检验科,四川成都610072

出　　处：《中国微生态学杂志》2013年第1期122-124,F0003,共4页Chinese Journal of Microecology

摘　　要：鲍曼不动杆菌对碳青霉烯类抗生素耐药率逐年增高,其主要耐药机制包括产生水解药物的碳青霉烯酶,外膜孔蛋白的改变,主动外排系统的过度表达和青霉素结合蛋白改变等。其中由于苯唑西林酶(Oxaclillinase,OXA酶)克隆传播导致鲍曼不动杆菌对碳青霉烯类抗生素耐药的爆发流行的报道,已引起大家的广泛关注。本研究对耐碳青霉烯类鲍曼不动杆菌产OXA酶的研究现状作一阐述。The resistance rate of Acinetobacter baumanni to Carbapenem antibiotics is increasing year by year.The main mechanisms include production of carbapenem-hydrolysing oxacillinases,change of porin proteins and excessive expression of offlnx pumps,as well as change of penicillin-binding proteins.Among these mechanisms,the reports on the outbreak of multi-drug resistant A.baumannii due to the spread of clones of the oxaclillinase had attracted extensive attention.In this paper,we reviewed the research advances of oxaclillinase in Carbapenem-resistant Acinetobacter baumannii.

关 键 词：鲍曼不动杆菌 碳青霉烯类抗生素 OXA酶 

分 类 号：R378[医药卫生—病原生物学]