离散事件仿真模拟的基本组成元素及其在药物经济学评价中的应用实例分析  

Basic Elements of Discrete Event Simulation and Case Analysis of Application of It in Pharmacoeconomics Evaluation

作　　者：赵子影[1,2] 彭六保[1,2] 曾小慧[1,2] 万小敏[1,2] 

机构地区：[1]中南大学湘雅二医院药学部,长沙410011 [2]中南大学湘雅医学院药学院,长沙410013

出　　处：《中国药房》2013年第6期483-486,共4页China Pharmacy

基　　金：国家自然科学基金资助项目(No.81173028)

摘　　要：目的:阐述离散事件仿真模拟(DES)的基本组成元素,为DES在药物经济学中的应用提供参考。方法:参考国内、外相关文献,介绍DES的基本组成元素及运行,与Markov模型相比较,并结合具体实例阐述DES在药物经济学中的运用。结果:DES能较好地模拟慢性疾病的进展过程,特别适用于对临床干预远期效果的决策评价。结论:运用DES进行药物经济学研究,可以丰富我国药物经济学研究内容。OBJECTIVE. To interpret the basic elements of discrete event simulation （DES）, and to provide reference for the appli- cation of DES in pharmacoeconomics. METHODS： Domestic and foreign literatures were reviewed to introduce basisc elements and oper- ation of DES, which was compared with Markov model, and interpret the application of DES in pharmacoeconomics based on special ex- ample.RESULTS.DES could simulate the development of chronic disease, especially for decision-making evaluation of long-term clinical intervention. CONCLUSION： DES applied for pharmacoeconomic study is conducive to the development ofpharmacoeconomics in China.

关 键 词：离散事件仿真模拟 药物经济学 慢性疾病 

分 类 号：R956[医药卫生—药学]