应用蒙特卡罗模拟法优化产ESBLs肠杆菌感染的拉氧头孢给药方案  

Optimization of Latamoxef Regimens for ESBLs-producing Enterbacteriaceae Infection by Monte-carlo Simulation Method

作　　者：陈世文[1] 范佳清[1] 

机构地区：[1]重庆市急救医疗中心药剂科,重庆400014

出　　处：《中国药房》2013年第6期509-511,共3页China Pharmacy

摘　　要：目的:评估拉氧头孢抑制产超广谱β-内酰胺酶(ESBLs)菌株的活性,优化其给药方案。方法:收集产ESBLs的菌株,采用肉汤稀释法测定最低抑菌浓度(MIC),通过蒙特卡罗模拟(MCS)法评估了拉氧头孢每个稳定状态下游离药物浓度(%fT>MIC)的目标达成概率。结果与结论:根据MCS结果,在70%fT>MIC获得80%目标达成率的有效给药方案是:每12小时输注1g剂量,输注时间超过3～4h,用于抗大肠杆菌;每8小时输注1g剂量,输注时间超过2～4h,用于抗肺炎克雷伯菌。OBJECTIVE： To evaluate latamoxef inhibiting the activity of Extended spectrum-β-lactamase （ESBLs）-producing strains, and to optimize the medication regimens. METHODS： ESBLs-producing strains were collected and MIC of them was deter- mined by broth dilution method. The probability of each %fT〉M,c goals of latamoxef was evaluated with Monte-carlo simulation method （MCS）. RESULTS ＆ CONCLUSION： According to MCS results, the effective medication regimen with 70%fT〉MIC of 80% target yield rate was as follows： infusing 1 g every 12 hours, infusing for more than 3-4 h, resisting to Escherichia coli; in- fusing 1 g every 8 hours, infusing for more than 2-4 hours, resisting Klebsiella pneumoniae.

关 键 词：蒙特卡罗模拟 拉氧头孢 超广谱Β-内酰胺酶 大肠杆菌 肺炎克雷伯菌 

分 类 号：R378.2[医药卫生—病原生物学] R446.5[医药卫生—基础医学]