瑞舒伐他汀与阿托伐他汀对冠心病患者Rho激酶活性和内皮功能影响的比较  

Effect of Rosuvastatin Versus Atorvastatin on ROCK Activity and Endothelial Function in Patients with Atherosclerosis

作　　者：吴丁烨[1] 冯健 尤华彦[1] 王强 曹华明[1] 钟艳芳[2] 

机构地区：[1]南京医科大学附属无锡人民医院心血管内科,江苏省无锡市214023 [2]南京医科大学附属无锡人民医院神经内科,江苏省无锡市214023

出　　处：《中国动脉硬化杂志》2013年第1期52-56,共5页Chinese Journal of Arteriosclerosis

摘　　要：目的比较稳定型心绞痛患者短期服用瑞舒伐他汀与阿托伐他汀对血脂、炎症标志物、血管内皮功能的影响。方法对36例稳定型心绞痛患者随机分为瑞舒伐他汀组(10 mg)和阿托伐他汀组(20 mg);服药前及服药4周后分别测量血脂、高敏C反应蛋白、Rho激酶活性、肱动脉血流介导的舒张功能。结果与治疗前比较,两组中总胆固醇、低密度脂蛋白胆固醇、甘油三酯和高敏C反应蛋白水平均明显降低,高密度脂蛋白胆固醇明显升高,肱动脉血流介导的舒张功能明显增加。两组中Rho激酶活性均显著降低,其中瑞舒伐他汀组的降低幅度更为显著(P<0.05)。两组中均发现Rho激酶活性与低密度脂蛋白胆固醇水平无相关性,而与肱动脉血流介导的舒张功能有明显相关性,肱动脉血流介导的舒张功能与低密度脂蛋白胆固醇水平和高敏C反应蛋白水平无相关性。结论动脉粥样硬化患者短期服用瑞舒伐他汀与阿托伐他汀能抑制Rho激酶活性,改善内皮舒张功能,其中瑞舒伐他汀降低Rho激酶活性优于阿托伐他汀。Aim To compare the short-term effects of rosuvastatin and atorvastatin on serum lipids and markers of inflammation and endothelial function in patients with stable atherosclerosis. Methods Thirty-six patients with stable atherosclerosis were randomly assigned to receive 10 mg/day of rosuvastatin or 20 mg/day atorvastatin for 4 weeks. The change in the levels and patterns of lipoproteins, high-sensitivity C-reactive protein （hs-CRP）, Rho-associated coiled-coil- containing protein kinase activity（ ROCK）, and brachial artery flow-mediated dilation （FMD） of the brachial artery were assessed before and after statin therapy. Results Rosuvastatin and atorvastatin both significantly lowered levels of total cholesterol, low-density lipoprotein cholesterol, triglycerides, and hs-CRP from baseline values, and increased levels of hs-CRP and FMD. Both statins inhibited ROCK（ P 〈 0. 05） , the extent of inhibition was greater with rosuvastatin （ P 〈 0. 05）. ROCK and FMD was correlated to each other（P 〈 0.05）. But ROCK was not correlated with the levels of low density lipoprotein cholesterol（LDLC）. FMD was not correlated with the levels of LDLC adn hs-CRP. Conclusions Short-term treatment with either rosuvastatin or atorvastatin inhibits ROCK and improves endothelium dysfunction in patients with atherosclerosis. But rosuvastatin inhibits ROCK even more than atorvastatin.

关 键 词：瑞舒伐他汀 阿托伐他汀 内皮功能 Rho激酶活性 动脉粥样硬化 

分 类 号：R5[医药卫生—内科学]