应变率成像对家兔挤压伤后心肌受损评价的实验研究  

Experimental study on strain rate imaging in rabbits＇ myocardium after crush injury

作　　者：赖小今[1] 熊杰[2] 胡宗海[2] 郭进春[3] 陶杰[1] 梁燕[1] 廖明松[1] 邓旦[1] 陈重[1] 罗克枢[4] 李坤[5] 王超[5] 

机构地区：[1]成都军区总医院超声科,成都610083 [2]成都军区总医院检验科,成都610083 [3]成都军区总医院干部病房,成都610083 [4]成都军区总医院病理科,成都610083 [5]成都军区总医院中心实验科,成都610083

出　　处：《中华超声影像学杂志》2013年第1期67-70,共4页Chinese Journal of Ultrasonography

基　　金：四川省卫生厅基金课题（090009）

摘　　要：目的探讨兔挤压伤后不同时间点的心肌应变率，评估挤压伤后心脏继发损伤。方法新西兰家兔42只，雌雄不拘，应用自制挤压器具按标准制作挤压伤模型，42只家兔随机分为对照组、解压即刻、解压后6、12、24、48、72h共7组，每组6只，每只家兔均连续检测挤压前及解压后不同时间点左室心肌应变和应变率等情况。结果左室心肌感兴趣区域的应变和应变率在解压后12h至24h降至最低（P〈0．01）；72h后逐渐恢复并相对稳定在一定水平，但与对照组比较，左室心肌应变和应变率仍降低（P〈0．05）。结论挤压伤伤后12～24h是心肌受损的达峰时间段，超声应变率成像能较精准、客观地评价心肌收缩性能。Objective To study the rabbitst cardiac secondary damaged after crush injury at different time point by strain rate imaging. Methods Forty-two New Zealand rabbbits,female and male not confined,were random divided into seven groups including control group, and other six groups, including loosed pressure immediately, and at 6,12,24,48, and 72 hours after crush injury, and the left ventricular myocardial efficiency were detected by strain rate imaging consecutively at different time point. Results The left ventrieular myocardial strain and strain rate of the region of interestwere decreased lowest after loosed pressure 12 to 24 h（ P〈0.01）, and which were rised gradually after 72 h. Conclusions The rabbits＇ left ventrielular myocardial efficiency are obvious decreased after crush injury, and after loosed pressure 12 to 24 h are peak time. The left ventricular myocardial efficiency can be evaluated precisely and objectively by strain rate imaging.

关 键 词：超声心动描记术 心肌 挤压伤 应变率成像 

分 类 号：R642[医药卫生—外科学]