扩张型心肌病患者血清中高迁移率族蛋白B1、白细胞介素-6及肿瘤坏死因子-α的表达  

Expression of high mobility group box 1 protein,interleukin-6 and tumor necrosis factor-α in serum of patients with dilated cardiomyopathy

作　　者：吴辉[1,2] 杨俊[1,2] 丁家望[1,2] 李松[1,2] 杨简[1,2] 陈勇[1,2] 董武松[1,2] 童晓红[1,2] 吕志阳[1,2] 李莉[1,2] 李稳慧[1,2] 

机构地区：[1]三峡大学心血管病研究所 [2]宜昌市中心人民医院心内科,湖北宜昌443003

出　　处：《临床心血管病杂志》2013年第2期88-90,共3页Journal of Clinical Cardiology

基　　金：湖北省教育厅自然科学研究项目(No:B20111201)

摘　　要：目的:探讨扩张型心肌病患者血清中高迁移率族蛋白B1(HMGB1)、白细胞介素(IL)-6及肿瘤坏死因子(TNF)-α的表达变化及意义。方法:采用ELISA法分别检测35例扩张型心肌病患者及20例同期健康体检者血清中HMGB1、IL-6及TNF-α的表达水平。结果:扩张型心肌病患者血清中HMGB1、IL-6及TNF-α的表达水平明显高于同期健康体检者[(21.49±4.15)pg/ml∶(1.78±0.53)pg/ml,(152.1±37.6)ng/ml∶(31.5±10.2)ng/ml,(33.2±8.1)ng/ml∶(9.7±2.5)ng/ml,均P<0.01]。扩张型心肌病患者血清中HMGB1的表达与IL-6、TNF-α的表达呈正相关(r分别为0.713、0.658,均P<0.05)。结论:HMGB1及其后续的炎症反应可能参与了扩张型心肌病的病理生理进程。Objective： To investigate the change of high mobility group box 1 protein （HMGB1）, interleukin （IL）-6 and tumor necrosis factor （TNF）-a in serum of patients with dilated cardiomyopathy （DCM）. Method： Thirty-five consecutive DCM patients and 20 healthy people with matched age and sex were enrolled. Serum concentrations of HMGB1, IL-6 and TNF-a were measured by ELISA. Result： The serum concentration levels of HMGB1, IL-6 and TNF-a in DCM patients were higher than those in healthy people [（21.49±4.15）pg/ml vs （1.78±0.53）pg/ml, （152.1±37.6）ng/ml vs （31.5±10.2）ng/ml, （33.2±8.1）ng/ml vs （9.7±2.5）ng/ml, all P〈0.01]. There was significantly positive correlation between HMGB1 and IL-6 （r= 0. 713, P〈0.05）, TNF-a （r=0. 658, P〈0.05） in DCM patients. Conclusion： HMGB1 and its subsequent inflammation may play a role in the pathophysiological processes of DCM.

关 键 词：扩张型心肌病 高迁移率族蛋白B1 炎症 

分 类 号：R542.2[医药卫生—心血管疾病]