多孔铌基生物材料的制备及其性能研究  

Fabrication of niobium-based biological materials via impregnation and its properties

作　　者：熊建义[1] 欧阳建安[1] 王大平[1] 阮建明[2] 朱伟民[1] 费志强[1] 张洪[1] 

机构地区：[1]深圳市第二人民医院骨科,深圳市组织工程重点实验室,广东深圳518035 [2]中南大学粉末冶金国家重点实验室,长沙410083

出　　处：《中国临床解剖学杂志》2013年第1期89-94,共6页Chinese Journal of Clinical Anatomy

基　　金：深圳市科技计划项目资助(201002043);广东省科技计划项目资助(2010B031600028)

摘　　要：目的制备多孔铌并评价其相关性能。方法采用新型的泡沫浸渍法,以聚氨酯泡沫为载体制备出具有较高强度和良好生物相容性的多孔铌基材料。并借助分析天平、XRD、CS600碳硫测试仪和SEM对多孔铌的孔隙率、性能和微观结构进行了测试及观察,运用细胞生物学技术评价多孔铌的细胞生物相容性。结果多孔铌具有三维、连通孔隙结构且无任何杂质相,孔隙率为71.4%,孔径500μm,平均密度为2.45 g/cm3,具有与人体松质骨相匹配的弹性模量和抗压强度;多孔铌不影响成骨细胞的增殖、黏附和表型表达。结论多孔铌具有高孔隙率结构,良好的力学性能及细胞生物相容性。Objective to fabricate porous niobium and evaluate its properties. Methods Novel preparation of Polyurethane foam impregnated with niobium powders was used to fabricate the niobium-based materials, which have high strength and excellent biocompatibility. Analytical balance, XRD ,CS600carbon and sulfftr analyzer and SEM were used to characterize its porosity, properties and microstructure. Cell biology techniques were used to evaluate the biocompatibility of porous niobium. Reuslts There were three-dimensional, connected pore structure and pure phase in the porous niobium-based materials prepared by solid phase sintering. The porosity, pore size and average density was 71.4%, 500 μm and 2.45 g/cm3, respectively. The elastic modulus and compressive strength of three-dimensional connected porous Nb coincided with cancellous bone in mechanical properties. Porous niobium was suitable for the adhesion, growth and differentiation of osteoblasts. Conclusions Porous niobium possessed high porosity structure, good mechanical properties and biocompatibility.

关 键 词：多孔铌 泡沫 浸渍 生物相容性 

分 类 号：R687[医药卫生—骨科学]