顶复门原虫钙依赖蛋白激酶的研究进展  

Research Advances in Calcium-dependent Protein Kinases of Apicomplexa

作　　者：张念章[1] 陈佳[1,2] 王萌[1] 朱兴全[1] 黄思扬[1] 

机构地区：[1]中国农业科学院兰州兽医研究所家畜疫病病原生物学国家重点实验室甘肃省动物寄生虫病重点实验室,兰州730046 [2]华南农业大学兽医学院,广州510642

出　　处：《畜牧兽医学报》2013年第1期1-6,共6页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家自然科学基金项目(31230073;31172316;31101812);农业部农业科研杰出人才项目;中央级公益性科研院所基本科研业务费专项(2012ZL081);中国农业科学院院长基金项目

摘　　要：钙依赖蛋白激酶(Calcium-dependent protein kinases,CDPKs)是一类大的蛋白激酶家族,属于丝氨酸/苏氨酸类蛋白激酶,广泛存在于各种植物和原生动物中,参与多种生命活动的调控。随着生物信息学、分子生物学及基因工程的迅速发展,对顶复门原虫CDPKs的研究日益增多。研究结果表明,这类蛋白家族成员参与调控寄生虫入侵、外出宿主细胞、配子形成、宿主体内移行等顶复门原虫生活史的多个重要时期,其特殊的分子结构或可成为研究抗寄生虫疫苗或药物的候选靶标。本文以疟原虫、弓形虫和艾美耳球虫CDPKs为重点,综述了顶复门原虫CD-PKs的结构、功能及生物学意义,展望了顶复门原虫CDPKs的研究和应用前景,以期为研究顶复门原虫的致病机理及研发抗原虫生物制剂提供参考。Calcium of serine-threonine dependent protein kinases （CDPKs） are a large gene family, which is one kind protein kinases. CDPKs have a diverse array of functions in various plants and many protozoa. With the development of bioinformatics, molecular biology and gene engineering, increasing numbers of researches about CDPKs were published recently. Increasing evidence sug- gests that CDPKs can regulate many crucial steps of parasite＇s life cycle including host cell inva- sion and egress, gamete formation, and gliding motility. The special structure compared with proteins in human and mammal makes CDPKs an ideal target for novel vaccine and anti-parasite therapeutic drugs. This article reviews the structures, functions and applications of Apicompl- exa＇s CDPKs focusing on Plasmodium, Tozoplasma gondii and Eimeria, and prospects the re- search and application tendency, in order to provide references for the research of the pathogene- sis and biological agents against Apicomplexan parasites.

关 键 词：顶复门原虫 钙依赖蛋白激酶 致病抗理 

分 类 号：S852.72[农业科学—基础兽医学]