脱细胞基质在组织工程气管移植中的研究进展  

RESEARCH PROGRESS OF DECELLULARIZED MATRIX IN TISSUE ENGINEERED TRACHEA TRANSPLANTATION

作　　者：章方彪 张卫东 史宏灿 

机构地区：[1]扬州大学临床医学院胸外科,江苏扬州225001

出　　处：《中国修复重建外科杂志》2013年第2期223-226,共4页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(30672080;30972968;81170014);江苏省"六大人才高峰"高层次人才基金资助项目(2009128);江苏省"青蓝工程"学术带头人基金资助项目(20081215)~~

摘　　要：目的综述脱细胞基质在组织工程气管中的研究现状、进展及未来前景。方法广泛查阅脱细胞基质在组织工程气管研究中的相关文献,对不同脱细胞基质修复人和动物气管病损的研究现状进行综合分析。结果气管组织工程应用的脱细胞基质包括空肠、膀胱、主动脉和气管。结论脱细胞膀胱基质及空肠基质在修复气管小范围非环形病损中具有较好效果,脱细胞主动脉基质在长段气管病损中的应用还需进一步研究,脱细胞气管基质在长段气管病损中具有良好的应用前景。Objective To summarize the recent research situation and progress of decellularized matrix in tissue engineered trachea transplantation and to forecast the possible perspects. Methods Recent original articles about study and application for decellularized matrix in tissue engineered trachea were reviewed. The application and study of different decellularized matrices involved in animals or patients with tracheal lesions were elaborated. Results Decellularized matrices researched and applied in tissue engineered trachea include jejunum, urinary bladder, aorta, and trachea. Conclusion Decellularized urinary bladder matrix and jejunal matrix appears to be efficacious method for the patch repair of partial circumferential tracheal defects. The application of decellularized aortic matrix may need more study, and decellularized tracheal matrix has a bright future in long tracheal defects.

关 键 词：气管组织工程 脱细胞基质 空肠 膀胱 主动脉 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]