硅磷酸钙骨水泥固化性质及生物降解性  

Self-setting properties and in vitro degradability of apatite cements composited with tricalcium silicate

作　　者：杨洪[1] 江泳[1] 刘璨[1] 赵慧娟[1] 师明旭[1] 刘晓娜[1] 

机构地区：[1]河南师范大学生命科学学院,河南新乡453007

出　　处：《现代化工》2013年第1期65-67,共3页Modern Chemical Industry

摘　　要：共沉淀反应法制备硅酸三钙(C3S),研究了含硅酸三钙(C3S)的磷酸钙系(磷酸四钙+磷酸氢钙)骨水泥(CPC)材料的固化性质和在模拟体液(SBF)中浸泡后材料降解性。与CPC骨水泥相比,复合C3S骨水泥的固化时间延长,一定量的C3S可提高CPC的抗压强度。在模拟体液浸泡设定时间后,含C3S骨水泥降解率明显增加。含C3S的骨水泥水化反应产物有缺钙型羟基磷灰石(CDHA)相生成,因此有良好的生物相容性,有可能作为一种可降解的骨组织再生材料使用。Tricalcium silicate （Ca3 SiO5 , C3 S） is synthesized by coprecipatition method. A novel bioactive composite cement is obtained by incorporation of tricalcium silicate into an apatite cement composed of tetracalcium phosphate （ Ca4 （PO4） 2 O, TFCP） and anhydrous diealcium phosphate （CaHPO4, DCPA）. The setting properties of the new cements are studied. The degradation rate of the pastes soked in SBF is detected. The results indicate that setting times of composited cements are higher than that of pure apatite cement. And the compressive strength of the TTCP/DCPA/C3S composite paste increases with increasing the proportion of Ca S in a certain concentration range. Compared with Ca S-free pastes, the composite pates show significant increase in degradation rate under the soaking in simulated body fluid （SBF）. The composited cements is able to form calcium deficiency hydroxyapatite （CDHA）phase ans show good biocompability.

关 键 词：硅酸三钙 磷酸钙骨水泥 自固化 模拟体液浸泡 

分 类 号：O611.3[理学—无机化学]