高尿酸血症与颅内动脉粥样硬化性狭窄相关性研究  

Corrrelation between hyperuricemia and intracranial atherosclerotic stenosis

作　　者：张素平[1] 吴文法[1] 范红星[1] 吉章阁[1] 

机构地区：[1]暨南大学医学院附属广州市红十字会医院神经内科,广州510220

出　　处：《中国实用内科杂志》2013年第2期138-141,共4页Chinese Journal of Practical Internal Medicine

摘　　要：目的探究高尿酸血症与颅内动脉粥样硬化性狭窄的相关性。方法对2007年8月至2011年11月218例暨南大学医学院附属广州市红十字会医院神经内科收治的缺血性脑血管病患者行数字减影血管造影(DSA)检查,同时检测血糖、血脂、血尿酸水平。根据DSA结果,分为狭窄组和无狭窄组,狭窄组再分为轻、中、重度狭窄组,用非条件Logistic回归分析评价颅内动脉粥样硬化性狭窄的相关危险因素,并比较颅内动脉不同狭窄程度之间血尿酸水平。结果除年龄、高血压、糖尿病、血脂异常等危险因素外,高尿酸血症同样是颅内动脉粥样硬化性狭窄的独立危险因素(OR=1.981,P=0.039)。无狭窄组、轻度狭窄组、中度狭窄组、重度狭窄组血尿酸水平分别是(285.8±61.7)μmol/L、(301.1±70.2)μmol/L、(349.8±66.1)μmol/L、(389.9±84.9)μmol/L,各组之间比较差异有统计学意义(P<0.05)。结论高尿酸血症是颅内动脉粥样硬化性狭窄的独立危险因素,且水平可提示狭窄的严重程度。Objective To investigate the correlation between hyperuricemia and intracranial atherosclerotic stenosis Methods A total of 218 patients with iscbemic cerebrovascular disease who were admitted to the department of neurology, Affiliated Red Cross Hospital of Jinan University, between August 2007 and November 2011, underwent cerebral vascular digital detraction angiography （DSA） and assessment of serum glucose, uric acid and lipids. Patients were divided into group nonstenosis and group stenosis according to DSA findings, with the latter being further assigned to mild, moderate and severe stenosis subgroups. Non-conditional logistic regression was employed to assess the risk factors of intracranial atherosclerotic stenosis, and the among-subgroup difference in the level of serum uric acid was compared. Results Hyperuricemia was evidenced to be,in addition to age and presence of hypertension, diabetes and dyslipidemia, an independent risk factor of intracranial atheroselerotic stenosis （OR 1. 981, P = 0. 039 ）. The difference in the level of serum uric acid differed significantly （ P 〈 0. 05 ） between the subgroups （ [ 285.8 ± 61.7 ]μ mol/L for group non-stenosis, [ 301.1 ±70. 2 ] μmol/L for group mild stenosis, [ 349. 8 ± 66. 1] μmol/L for group moderate stenosis and [ 389. 9 ± 84. 91 μmol/L for group severe stenosis）. Conclusion Hyperuricemia is an independent risk factor of intracranial atherosclerotic stenosis and may indicate the severity of stenosis.

关 键 词：高尿酸血症 动脉粥样硬化性狭窄 血糖 血脂 血尿酸 

分 类 号：R541.4[医药卫生—心血管疾病]