氢化诺卜酸及其酰胺的合成  

Synthesis of hydronopic acid and its acidamide

作　　者：赵玲华[1] 肖转泉[2] 陈金珠[3] 王宗德[1] 范国荣[1] 陈尚钘[1] 

机构地区：[1]江西农业大学林学院,江西南昌330045 [2]江西师范大学化学化工学院,江西南昌330027 [3]江西农业大学理学院,江西南昌330045

出　　处：《化学研究与应用》2013年第2期245-248,共4页Chemical Research and Application

基　　金：国家自然科学基金项目(31060101)资助;教育部留学回国人员科研启动基金项目([2010]1561)资助;广西林产化学与工程重点实验室开放课题项目(GXFC11-07)资助

摘　　要：氢化诺卜醇(1)在醋酸溶液中被CrO3氧化制得氢化诺卜酸(2),由氢化诺卜酸与亚硫酰氯反应生成氢化诺卜酰氯(3),氢化诺卜酰氯分别与浓氨水、33%二甲胺水溶液、二乙胺和二异丙胺在冰水浴中反应制得相应的4种酰胺,各产物的得率均在70%以上,GC纯度95%以上。各产物均用IR,1H NMR,13C NMR与MS进行了结构表征。Hydronopic acid was synthesized from hydronopol by the oxidation of CrO3 in AcOH. Then hydronopic acyl chloride was synthesized from hydronopic acid and thionyl chloride. Finally, four hydronopic acidamide were synthesized from the reaction of hydronopic acyl chloride with 4 amines respectively. The yields of the 4 hydronopic acidamide were all no less than 70% （ GC con- tent were over 95% ）. All the structures were indentified by IR, ^1H NMR,^13C NMR and MS analysis.

关 键 词：氢化诺卜醇 氢化诺卜酸 酰胺 结构分析 

分 类 号：O621[理学—有机化学]