徐州市健康体检者肾功能下降状况及危险因素  

Prevalence and risk factors of reduced renal function among physical examinees in Xuzhou city

作　　者：卓朗[1] 董鑫[2] 杨科[2] 宋慧[2] 丁伟洁[2] 汪秀英[3] 陈茂杰[3] 

机构地区：[1]徐州医学院公共卫生学院卫生事业管理学教研室,江苏徐州221004 [2]徐州医学院 [3]徐州市中心医院肾内科

出　　处：《中国公共卫生》2013年第2期285-287,共3页Chinese Journal of Public Health

基　　金：徐州市科技发展基金(XF10C051)

摘　　要：目的了解江苏省徐州市健康体检者肾功能下降状况及其危险因素,为采取干预措施提供参考依据。方法收集徐州市中心医院2006—2009年77355名健康体检者体检资料进行回顾性分析。结果 77355名健康体检者肾功能下降患病率为1.18%,标化患病率为1.30%;其中男性和女性的患病率分别为1.19%和1.18%,差异无统计学意义(P>0.05);20～、30～、40～、50～、60～、70～和≥80岁年龄组患病率分别为0.10%、0.20%、0.52%、1.20%、3.30%、7.62%和11.58%,不同年龄组差异有统计学意义(χ2=2734.34,P=0.000);男性和女性肾功能下降率均随年龄的增长呈上升趋势(P=0.000),平均每10年分别增长1.85%和2.18%;多因素lo-gistic回归分析结果表明,血浆粘度偏高、蛋白尿、白细胞尿、红细胞尿、低密度脂蛋白偏高、空腹血糖偏高、收缩压偏高、血尿酸偏高是肾功能下降的危险因素。结论徐州市健康体检者肾功能下降患病率较低,有蛋白尿、白细胞尿、红细胞尿以及血浆粘度、低密度脂蛋白、空腹血糖、收缩压、血尿酸偏高是肾功能下降的危险因素。Objective To explore the prevalence rate and risk factors of reduced renal function（RRF） by retrospective analysis on data from a physical examination sample in Xuzhou city for the prevention of the disorder. Methods Totally 77 355 physical emaminees were selected to estimate glomerular filtration rate（eGFR） by retrospective analysis from 2006 -2009. Results The prevalence rate of RRF among the participants was 1.18% with a standardized rate of 1.30% （1.19% for male and 1.18% for female） and there was no significant gender difference in the rate（P 〉0. 05）. The prevalence rate of RRF for the participants of 20 - ,30 - ,40 - ,50 - ,60 - ,70 - and ~〉80 age groups was 0. 10%, 0. 20% ,0. 52%, 1.20%, 3.30%, 7.62%, and 11.58%, respectively, and there were significant differences among the age groups（P =0. 000）. The prevalence of RRF increased with the increment of age with an increase rate 1.85% per 10 years for the male and 2. 18 for the female. The results of logistic regression showed that high plasma viscosity ,proteinuria,red blood cell urine,white blood cell urine,high low density lipoprotein,high fasting blood glucose,high systolic blood pressure,and serumuric acid were independently associated with RRF. Conclusion The prevalence rate of RRF in Xuzhou is lower than that of other reports. High plasma viscosity,proteinuria,red blood cell urine,white blood cell urine,high low density lipoprotein, high fasting blood glucose,high systolic blood pressure,and serumuric acid are independently associated with RRF.

关 键 词：肾功能下降 危险因素 健康体检者 

分 类 号：R195[医药卫生—卫生统计学]