4种中心原子不同的钨铋酸杂多酸毒性及对新城疫病毒的抑制试验  

Toxicity of Bismuth Tungsten Acid Heteropoly Acid with Four Different Central Atoms and Its Inhibition Test on Newcastle Disease Virus

作　　者：程广东[1] 岳丽红[1] 刘海燕[2] 刘风华[2] 张瑞仁[2] 缪月英[2] 宋春香[2] 刘红[2] 

机构地区：[1]佳木斯大学生命科学学院,黑龙江佳木斯154007 [2]佳木斯大学药学院,黑龙江佳木斯154007

出　　处：《畜牧与饲料科学》2013年第1期7-9,共3页Animal Husbandry and Feed Science

基　　金：黑龙江省自然科学基金面上项目(B200917);黑龙江省教育厅课题(11551484;11551502);黑龙江省卫生厅课题(2012-267);佳木斯市社科联项目(11056);佳木斯大学科学技术面上项目(S2011-052)

摘　　要：为了研究4种中心原子不同的钨铋酸杂多酸毒性及抗新城疫病毒活性,选择体重为(22±1)g小鼠24只,随机分成4组,每组6只,每组小鼠分别采用灌胃BiW9、BiW9Cu3、SbW9Cu3、BiW9Co3(IM)3来检测化合物急性毒性,通过血凝和血凝抑制试验检测化合物药效。结果表明,BiW9、BiW9Cu3、SbW9Cu3、BiW9Co3(IM)3引起小鼠2/6死亡的剂量分别为(7776.0±12.6)mg/kg、(2379.0±11.2)mg/kg、(3243.0±12.3)mg/kg、(7056.0±15.4)mg/kg,当抗病毒效价为1/16时,BiW9、BiW9Cu3、SbW9Cu3、BiW9Co3(IM)3的浓度分别为(29.14±0.63)mg/mL、(1.80±0.06)mg/mL、(1.86±0.04)mg/mL、(4.41/±0.11)mg/mL。结论为4种不同过渡金属取代的钨铋酸杂多酸均为低毒化合物,但是具有抗新城疫病毒活性,并且具有较高的药效。To study the toxicity of bismuth tungsten acid heteropoly acid with different Jiamusi University,four central atoms and its antibacterial activity against newcastle disease virus, 24 mice with the body weight of （22＋ 1 ） g were randomly divided into 4 groups （6 mice in each group）. Mice in these four groups were administrated with BiWg, BiWgCu3,SbW9Cu3,BiWgCo3 （IM）3 respectively by intragastric administration to detect the acute toxicity of compounds. And the efficacy of compounds was detected by hemagglutination test and hemagglutination inhibition test. The results showed that the dosage of BiWg, BiWgCu3, SbWgCu3, BiWgCo3（IM）3 the caused of the death of 2/6 mice were （7 776.0±12.6）, （2 379.0＋11.2）, （3 243.0±12.3） and （7 056.0±15.4） mg/kg respectively. When the antivirus titer was 1/16, the concentration of BiWg, BiWgCu3, SbWgCu3, BiWgCo3 （IM）3 were （29.14± 0.63 ）, （1.80±0.06）, （1.86±0.04） and （4.41 ±0.11 ） mg/mL respectively. In conclusion, bismuth tungsten acid heteropoly acid substituted by four different transition metals was low toxic compound, but it had antibacterial activity against newcastle disease virus and high efficacy.

关 键 词：中心原子 钨铋酸 杂多酸 毒性 新城疫病毒 

分 类 号：S859[农业科学—临床兽医学]