糖尿病肾病患者钙调节激素和胱抑素C相关性分析  

Correlation analysis of calcium-regulating hormones and cystatin C in patients with diabetic nephropathy

作　　者：田华[1] 

机构地区：[1]陕西省宝鸡市人民医院检验科,721000

出　　处：《国际检验医学杂志》2013年第3期300-301,304,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨胱抑素C(CysC)、尿微量清蛋白(UmAlb)、降钙素(CT)、骨钙素(BGP)在评估糖尿病肾病钙磷代谢中的意义及相关性。方法观察组为糖尿病肾病(Ⅰ～Ⅳ期)患者98例,对照组为社区健康人群50例,分别检测血CysC、CT、BGP及UmAlb。结果观察组患者CysC及UmAlb显著高于对照组(P<0.01),观察组CT及BGP较对照组显著升高(P<0.05)。观察组内糖尿病肾病Ⅱ、Ⅲ、Ⅳ期患者CysC及UmAlb均较糖尿病肾病Ⅰ期患者显著升高(P<0.05),糖尿病肾病Ⅲ、Ⅳ期患者CT及BGP较糖尿病肾病Ⅰ期患者显著升高(P<0.05)。血清CysC与CT相关系数为0.487,与BGP相关系数为0.563,UmAlb与CT相关系数为0.384,与BGP相关系数为0.646,均呈正相关(P<0.05)。结论 CysC、UmAlb、CT、BGP联合检测有助于评估糖尿病肾病进展及早期发现钙磷代谢紊乱。Objective To investigate the significance and correlation of cystatin C（Cys C） ,urinary albumin（UmAlb） ,calcitonin （CT） ,osteocalcin（BGP） in the assessment of diabetic nephropathy calcium and phosphorus metabolism. Methods 98 patients were included in the group of diabetic nephropathy（ I -- IV ）, a total of 50 cases of research objects were included in the control group from the community healthy population. Blood Cys C, CT,BGP and urine UmAlb were detected. Results Cys C, UmAlb in observa- tion group were significantly higher than those in control group（P〈0.01） ,CT and BGP in observation group was significantly in- creased than those in control group（P〈0.05）. The Cys C and UmAlb in patients with diabetic nephropathy phase Ⅱ , Ⅲ and IV was significantly higher, compared with patients with diabetic nephropathy stage I,CT and BGP of patients with diabetic nephropa- thy phase III and IV was significantly higher than those in patient at phase I （P〈0.05）. Correlation coefficient of serum Cys C and CT was 0. 487 ,the correlation coefficient with BGP was 0. 563, correlation coefficient of UmAlb with CT was 0. 384 ,the corre- lation coefficient with BGP was 0. 646（P〈0.05）. Conclusion Combined detection of Cys C,UmAlb,CT and BGP could help to early detection of calcium and phosphorus metabolism and assess the progress of diabetic nephropathy.

关 键 词：糖尿病肾病 半胱氨酸蛋白酶抑制剂 降钙素 骨钙素 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]