福建闽西地区儿童全血铜、锌、钙、镁、铁微量元素参考范围调查  

Reference intervals for blood copper,zinc,calcium,magnesium and iron in infants and children of Fujian west area

作　　者：吴定昌[1,2] 肖婷[1,2] 王跃华[1,2] 郑艳斌[1,2] 郭笑如[1,2] 兰小鹏 

机构地区：[1]福建医科大学附属龙岩第一医院检验科 [2]福建省龙岩市第一医院,福建龙岩364000 [3]南京军区福州总院检验科,福建福州350025

出　　处：《国际检验医学杂志》2013年第3期317-319,共3页International Journal of Laboratory Medicine

摘　　要：目的调查福建闽西地区儿童年龄特异性全血铜(Cu)、锌(Zn)、钙(Ca)、镁(Mg)、铁(Fe)微量元素正常参考范围。方法利用BH5300S原子吸收光谱仪分析福建闽西地区1702例1个月至11岁健康儿童的全血Cu、Zn、Ca、Mg、Fe微量元素浓度。结果经统计得到福建闽西地区儿童年龄特异性全血Cu、Zn、Ca、Mg、Fe微量元素参考范围。分析全血微量元素与年龄的相关性,发现Cu和Fe元素与年龄呈负相关(P<0.05),Zn和Ca元素与年龄呈正相关(P<0.05),未发现全血Mg元素浓度与年龄相关性(P>0.05)。经统计优化后,各元素参考范围年龄段划分减少。结论全血Cu、Zn、Ca、Mg、Fe微量元素参考范围的建立可为儿童微量元素合理补充提供指导,特别为福建闽西地区儿童微量元素缺乏的实验室诊断和流行病学调查提供重要依据。Objective To study and establish the age-specific reference intervals for blood copper（Cu） ,zinc（Zn） ,calcium（Ca）, magnesium（Mg） and iron（Fe） in infants and children of Fujian west area. Methods Blood concentrations of Cu,Zn,Ca,Mg and Fe were measured by BH5300s atomic absorption spectrometry from 1 702 healthy infants and children（aged 1 month to 11 years） of Fuzhou area. Results Age-specific reference intervals suitable for Fujian west area were established for Cu, Zn,Ca, Mg and Fe. Studying on the effects of age on blood element concentrations revealed that there were inverse correlations between age and blood concentrations of Cu and Fe, positive correlation between age and blood concentrations of Zn and Fe,and no correlation between age and blood concentration of Mg. The numbers of age divisions for each trace element reference interval were reduced effectively by statistical optimization. Conclusion Established reference intervals for Cu, Zn, Ca, Mg and Fe can provide important guidance for the reasonable supplementation of trace elements, and form the basis for the accurate clinical diagnosis and epidemiological survey of infants and children trace element deficiency in Fujian west area clinical decision-making important.

关 键 词：痕量元素 参考范围 福建 

分 类 号：R446.1[医药卫生—诊断学]