麻杏石甘汤解热作用量效关系研究  

The Research on Dose-effect Relationship of Maxing Shigan Tang in Relieve Fever

作　　者：屈飞[1] 崔艳茹 徐镜[3] 徐国良[3] 黄丽萍[1] 余日跃[1] 

机构地区：[1]江西中医学院药学院药理学教研室,南昌330004 [2]江西中医学院基础医学院生理学教研室,南昌330004 [3]江西中医学院现代中药制剂教育部重点实验室,南昌330004

出　　处：《中国实验方剂学杂志》2013年第3期184-187,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家重点基础研究发展计划(973计划)(2010CB530600)

摘　　要：目的:观察麻杏石甘汤对内毒性发热SD大鼠的体温及血浆前列腺素E2(PGE2)水平的影响,并探讨其量效关系。方法:将66只大鼠随机分为11组,空白对照组,模型组,剂量1组～剂量9组,每组6只,空白对照组尾静脉注射生理盐水,另10组均采用尾静脉注射内毒素的方法制成发热大鼠模型,分别灌胃相应量生理盐水或麻杏石甘汤。观察比较各组体温和6.0 h体温反应指数(TRI6.0)变化,并测定血浆PGE2水平。结果:与模型组相比,麻杏石甘汤剂量1至剂量9能明显降低发热大鼠的最大温差(ΔTmax)和TRI6.0,麻杏石甘汤存在量效关系,且降温效应为多波折曲线。此外,麻杏石甘汤能剂量依赖性降低血浆PGE2水平。结论:不同剂量麻杏石甘汤对内毒素性发热SD大鼠的解热作用为多波折量效关系。Objective： To investigate on temperature and prostaglandin E2 （PGE2） contents in plasma of rats with endotoxic fever in Maxing Shigan Tang, and found the dose-effect relationship. Method： Sixty-six rats were randomly divided into 11 groups, of which with 6 ： control group, model group, dose 1-dose 9 groups. The control group was injected normal saline, the other group with endotoxin; dose groups were administrated with Maxing Shigan Tang of different doses. ATma~ and thermal response index （TRI） were observed. The levels of plasma PGE2 was determined. Result： Compared with control group, dose 1-dose 9 group could depress ATmax and TRI significantly. The effect had dose-effect relationship and showed many twists and turns. In addition, Maxing Shigan Tang could lower the level of PGE2 with dose-effect. Conclusion： Different doses of Maxing Shigan Tang have antipyretic effect of dose-effect relationship for the many twists and turns to fever rats.

关 键 词：麻杏石甘汤 体温 血浆前列腺素E2 

分 类 号：R285.5[医药卫生—中药学]