香连胶囊对大鼠急性肠炎的作用  

Effects of Xianglian Capsule on Acute Enteritis in Rat Models

作　　者：王欣[1] 王伟明[1] 宋亚娟[1] 张丹丹[1] 张树明[1] 张雅丽[1] 

机构地区：[1]黑龙江省中医研究院,哈尔滨150036

出　　处：《中国实验方剂学杂志》2013年第3期212-215,共4页Chinese Journal of Experimental Traditional Medical Formulae

摘　　要：目的:观察香连胶囊对大鼠溃疡性结肠炎的疗效及其抗炎、镇痛、止泻作用。方法:大鼠随机分为正常对照组、模型组、泻痢消片组,香连低、中、高剂量组(0.122,0.243,0.486 g.kg-1),用乙酸法建立大鼠乙酸性结肠炎模型。连续给药10d后麻醉处死动物,观察大鼠结肠形态的变化并进行结肠黏膜损伤指数(CMDI)评分,测定大鼠结肠质量,HE染色病理观察。采用二甲苯致小鼠耳廓肿胀模型、番泻叶致小鼠腹泻模型,小肠推进实验及小鼠醋酸扭体实验观察其药效。结果:与模型组比较,香连胶囊中剂量组能够明显减轻醋酸对大鼠肠黏膜的损伤,减轻炎症坏死,水肿及炎细胞浸润;香连胶囊中剂量组抑制二甲苯所致小鼠耳肿胀(P<0.01)、减少番泻叶致小鼠腹泻次数(P<0.05)、缩短小肠推进距离(P<0.05),减少醋酸引起的小鼠扭体次数(P<0.01)。结论:香连胶囊有明显的抑制溃疡,抗炎,镇痛作用及抑制肠蠕动的作用,是治疗肠炎的有效药物。Objective： To .investigate the therapeutic effects of Xianglian capsule on acute ulcerative colitis, anti-inflammatory, analgesic and anti-diarrheal functions. Method： Sixty SD rats were randomly divided into normal control group, model group, Xieli-xiao group, low, medium, high doses of Xianglian group （0. 122, 0. 243, 0. 486 g kg-1）. Using acetic acid method to establish the rat models of ulcerative colitis. Gross morphological changes of rat colon and colonic mucosal damage index （CMDI） score, and rat colon weight, pathology was observed after after continuous administration for 10 days. Anti-inflammatory, analgesic and anti- diarrheal efficacys were observed with ear swelling models induced by xylene, diarrheal models induced by senna and acetic acid writhing test. Result： Compared with the model group, the Xianglian capsule medium dose group （0. 243 g kg-1） can obviously reduce on rat intestinal mucosal damage induced by acetic acid, reduce inflammation, necrosis, edema and inflammatory cell invasion; Xianglian capsule medium dose group （0. 243 g kg-1） inhibited the degree of ear swelling （P 〈 0.01 ）, decrease frequency of diarrhea （P 〈 0.05）, shortened small intestine advance distance （P 〈 0.05 ） , reduce the writhing times of （P 〈 0.01 ）. Conclusion ： Xianglian capsule can significantly inhibit the ulcer and have anti-inflammatory, analgesic action and inhibition of intestinal peristalsis.

关 键 词：香连胶囊 溃疡性结肠炎 抗炎 小肠推进 镇痛 

分 类 号：R285.5[医药卫生—中药学]