基于决策规则模型及均匀设计拆方的右归丸配伍规律研究  

Study on the Law of Compatibility in Yougui Pill based on Decision Rules Model and Uniform Design

作　　者：王秀凤[1] 张磊[1] 唐小娅[1] 邓树泳[1] 罗来成[1] 

机构地区：[1]广东药学院,广州510006

出　　处：《中国实验方剂学杂志》2013年第3期321-324,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(30973977)

摘　　要：目的:利用基于粗糙集理论的决策规则模型评价右归丸的疗效,探究其中补阴药、补阳药和边缘药的相互作用及地位,进而改进右归丸的配伍。方法:把大鼠分为正常组、肾阳虚模型组、右归丸原方组以及右归丸均匀设计的药方组5组,共8组。分别检测其四碘甲腺原氨酸(T4),皮质醇(CORT)和睾酮(T)。建立基于粗糙集的决策规则模型,通过决策规则分析补阴药、补阳药和边缘药3者之间的相互作用。结果:右归丸中补阴药和补阳药之间具有协同作用;同时右归丸的边缘药对补阴药有促进作用;当右归丸的补阳药药量较小时,边缘药对其有促进作用,当补阳药药量较大时边缘药与补阳药之间有拮抗作用。结论:右归丸的配伍应注重阴阳并补、阴阳互济,补阴补阳同样重要;同时要根据右归丸中补阳药的药量来确定合适的边缘药药量,以提高整个复方的药效。Objective： To evaluate the efficacy of Yougui pill with decision rules model based on rough set, to explore the interactions and position of the Yin-tonifying herbs, the Yang-tonifying herbs and the edge herbs, and then to improve the compatibility of Yougui pill. Method： The rats were divided into 8 groups, ie normal group, model group of kidney-yang deficiency, the original prescription group and five prescription groups by uniform design of Yougui pill. T4, CORT and T values were detected respectively. The decision rules model based on rough set was set up. The interactions among the Yin-tonifying herbs, the Yang-tonifying herbs and the edge herbs were analyzed according to the decision rules. Result： There were synergies between the Yin-tonifying herbs and the Yang-tonifying herbs in Yougui pill. There were synergies between the edge herbs and the Yin- tonifying herbs. There were synergies between the edge herbs and the Yang-tonifying herbs when the amount of the Yang-tonifying herbs were small, while the edge herbs antagonistic with the Yang-tonifying herbs when the amount of the Yang-tonifying herbs were large in Yougui pill. Conclusion： The compatibility of Yougui pill should focus on benefiting both yin and yang, as well as mutual rooting of Yin-yang. The amount of the edge herbs was determined according to the amount of Yang-tonifying herbs in order to improve the efficacy of Yougui pill.

关 键 词：肾阳虚 右归丸 补阴药 补阳药 均匀设计 粗糙集 决策规则 

分 类 号：R287.6[医药卫生—中药学]