α-常春藤皂苷丙烯酸树脂纳米粒的制备及其体外评价  

Preparation and in vitro evaluation of saponins PD-loaded Eudragit S100 nanoparticles

作　　者：耿丽娟[1] 唐丽华[1] 游本刚[1] 邵轶男[1] 李玲[1] 

机构地区：[1]苏州大学医学部药学院,苏州215123

出　　处：《中国新药杂志》2013年第3期367-372,共6页Chinese Journal of New Drugs

基　　金：国家自然科学基金青年基金(81102818);苏州大学大学生课外学术科研基金(KY2011374B)

摘　　要：目的:制备和评价α-常春藤皂苷(saponins PD,SPD)丙烯酸树脂S100纳米粒(SPD-S100-NPs)。方法:采用改良乳化-溶剂扩散法制备纳米粒,以粒径大小、包封率(entrapment efficiency,EE)和多分散指数(polydisperse index,PI)为指标,通过单因素试验和正交试验设计优化制备工艺。以红外光谱(fouriertransform infrared spectrometer,FT-IR)、X射线衍射(X-ray diffraction,XRD)、差示扫描量热分析(differentialscanning calorimetry,DSC)、体外释放试验等对纳米粒的相关性质进行评价。结果:制备的纳米粒外观圆整,平均粒径(73.1±4.6)nm,包封率(99.0±0.58)%,PI值(0.249±0.029)。药物在纳米粒中均被载体材料有效包裹,其体外释放具有显著的pH依赖性。结论:改良乳化-溶剂扩散法制备了包封率高、大小均匀的pH依赖性α-常春藤皂苷纳米粒。Objective： To prepare and evaluate saponins PD-loaded Eudragit S100 nanopartieles （SPD- S100-NPs）. Methods：The SPD-S100-NPs were prepared by modified quasi-emulsion solvent diffusion technique. Taking particle size,entrapment efficiency （EE） and polydisperse index （PI） as comprehensive indexes, orthogo- nal test design was used to optimize the preparation process. The characteristics of SPD-S100-NPs were determined by FT-IR, XRD, DSC, etc. ; and the in vitro drug release of nanoparticles colloid was investigated. Results ： The nan- opartieles were spherical, with average particle size of （73. 1 ±4.6） nm, EE of （99. 0 ±0.58）%,and PI of （0. 249 ± 0. 029）. The release of SPD significantly depended on pH. Conclusion： SPD-S100-NPs with high en- trapment efficiency,homogeneous size distribution and pH-dependant release characteristics can be prepared by this method.

关 键 词：α-常春藤皂苷 丙烯酸树脂S-100 纳米粒 释放 表征 

分 类 号：R94[医药卫生—药剂学]