V型狼疮性肾炎患者外周血Th1/Th2因子的变化及意义  

Expression of Th1 and Th2 cytokines in serum of patients with lupus nephritis

作　　者：李华[1] 吴扬[1] 宋小红[1] 李承旭[1] 蔡源[1] 陈铖[2] 

机构地区：[1]华中科技大学同济医学院附属普爱医院肾内科,湖北武汉430034 [2]武汉大学人民医院肾内科

出　　处：《现代预防医学》2013年第4期746-747,752,共3页Modern Preventive Medicine

摘　　要：目的采用流式细胞小球微阵列术(cytometric Bead Array,CBA)检测V型狼疮性肾炎(LN)患者外周血Th1/Th2细胞因子的表达并探讨其意义。方法用CBA法检测20例V型LN患者和20例正常人血清中Th1(TNFα、IFN-γ)和Th2(IL4和IL5)类细胞因子表达情况。结果 V型LN组Th1类细胞因子TNFα和IFNγ表达均高于正常对照组,而正常对照组中IL4和IL5则高于狼疮肾患者。结论 Th1和Th2类细胞因子平衡/紊乱在狼疮肾患者肾组织损害中可能起一定作用。CBA法检测Th1/Th2细胞因子是一种高效、简便和敏感度高的方法。OBJECTIVE To investigate the crucial role of Thl and Th2 cytokines in systemic lupus erythematousus （SLE） pa- tients with renal damage. METHODS The levels of parts Thl and Th2 cytokines in serum from 20 SLE patients with renal dam- age and 20 healthy controls were measured by CBA. RESULTS The levels of TNFct ＆ IFN~/from SLE patients with renal dam- age were higher than that of healthy controls, while IL4 ＆ IL5 in SLE patient group were lower compared with healthy group. CONCLUSION Increased TNFct ＆ IFN＇,/companied with decreased IL4 ＆ IL5 in peripheral blood may play an important role in the pathogenesis of lupus nephritis （LN） patients.

关 键 词：流式细胞小球微阵列术 系统性红斑狼疮 狼疮性肾炎 TH1 TH2细胞因子 

分 类 号：R593.242[医药卫生—内科学]