Modic改变在腰椎间盘退变中的意义  

The significance of Modic change in lumbar disc degeneration

作　　者：马铮[1] 丁文元[1] 杨大龙[1] 孙亚澎[1] 张立军 

机构地区：[1]河北医科大学第三附属医院脊柱外科,石家庄050000 [2]石家庄中心医院骨科

出　　处：《中国骨与关节杂志》2013年第1期40-43,共4页Chinese Journal of Bone and Joint

摘　　要：腰椎退变性疾病发病率在60岁以上人群中可达90％，随着对其研究的深入，发现椎体终板Modic改变在腰椎退变性疾病中发生率较高，本文就Modic改变在腰椎间盘退变中的意义进行综述。Concerning the Modic change of lumbar spinal endplate, the Modic change types, forming causes, and the relationship between Modic change and degenerative lumbar diseases have been studied from anatomy, pathology, molecular biology and many other aspects at present. The degeneration of lumbar disc is a high risk factor of the Modic change. The degeneration of lumbar disc usually starts from cartilage endplate degeneration. The injury of cartilage endplate could accelerate the degeneration of lumbar disc. This article reviews the significance of Modic change of lumbar spinal endplate in lumbar disc degeneration. The cause of Modic change of the endplate, pathological change, the influence of inflammatory mediators on the endplate and the significance of Modic change in the treatment of degenerative lumbar diseases are summarized to analyze the relationship between the degeneration of lumbar disc and Modic change of endplate and to describe the influence of Modic change in the treatment of degenerative lumbar disc diseases.

关 键 词：MODIC改变 腰椎间盘退变 腰椎退变性疾病 疾病发病率 椎体终板 发生率 

分 类 号：R681.53[医药卫生—骨科学]