针刺四缝穴对厌食症患儿食欲调节因子的影响  

Impacts on the appetite regulating factors of infantile anorexia treated with acupuncture at Sifeng(EX-UE 10)

作　　者：付美鸳[1] 胡国华[1] 周向锋[1] 何宝祥 何立星 黄炳伦[1] 高素华[1] 

机构地区：[1]金华职业技术学院医学院临床实验室,浙江金华321017 [2]兰溪市第三医院满塘岗社区服务站

出　　处：《中国针灸》2013年第2期117-120,共4页Chinese Acupuncture & Moxibustion

基　　金：浙江省金华市科技局基金资助项目:2011-3-058

摘　　要：目的:探讨针刺四缝穴对小儿厌食症血清中食欲调节因子水平的动态变化及临床疗效。方法:选取3～6岁符合诊断标准的患儿80例,随机分为针刺组与儿康宁组各40例,另设健康对照组30例。针刺组采用三棱针点刺四缝穴,刺后挤出少许淡黄色或透明黏液,或者少许血液,每周治疗1次,治疗4周;儿康宁组给予儿康宁糖浆,每天3次,治疗4周。观察各组治疗前后血清促人生长激素腺释放肽(Ghrelin)、瘦素(Leptin)、神经肽Y(NPY)变化情况及临床疗效。结果:针刺组与儿康宁组治疗前Ghrelin、NPY明显低于健康对照组(均P<0.01),而Leptin明显高于健康对照组(P<0.01);治疗后针刺组Ghrelin、NPY明显高于治疗前(均P<0.01),Leptin较治疗前明显降低(P<0.01);针刺组以上指标治疗后较儿康宁组改善更明显(均P<0.01)。针刺组与儿康宁组显效率分别是82.5%(33/40)和32.5%(13/40),总有效率分别是95.0%(38/40)与45.0%(18/40),针刺组均优于儿康宁组(均P<0.01)。结论:针刺四缝穴能有效促进Ghrelin、NPY的分泌,抑制Leptin产生,有效改善患儿的食欲状况,疗效优于儿康宁糖浆。Objective To explore the dynamic change and clinical efficacy of acupuncture at Sifeng （EX-UE 10） on appetite regulating factors in the serum of infantile anorexia. Methods Eighty cases, in compliance with the di- agnostic criteria, aged from 3 to 6 years were randomized into an acupuncture group and a medication group, 40 ca- ses in each one. Additionally, a healthy control group （30 cases） was set up. In the acupuncture group, the prick- ing method was adopted at Sifeng （EX-UE 10） with the three-edged needle. A few light yellow, transparent vis- cous liquid or blood was squeezed out after pricking. The treatment was given once a week, for 4 weeks totally. In the medication group, erkangning syrup was administered, 3 times a day, for 4 weeks totally. The ghrelin, leptin and neuropeptide Y （NPY）, and the clinical efficacy were observed before and after treatment in each group. Re- sults The levels of ghrelin and NPY before treatment in acupuncture group and the medication group were lower apparently than those in the healthy control group （all P^0.01）, but the level of leptin was higher appa-rently than that in the healthy control group （P^0.01）. After treatment, the levels of ghrelin and NPY were higher ap- parently than those before treatment in the acupuncture group （both P^0.01）, and the level of leptin was lower apparently than that before treatment （P^0.01）. All of the above indices in the acupuncture group were improved obviously after treatment as compared with those in the medication group （all P〈0.01）. The remarkable and ef- fective rate were 82.5% （33/40） and 32.5% （13/40） and the total effective rate were 95.0% （38/40） and 45.0% （18/40） in the acupuncture group and medication group separately, the results in the acupuncture group were su- perior to the medication group （both P〈0.01）. Conclusion Acupuncture at Sifeng （EX-UE 10） effectively pro- motes the secretion of ghrelin and NPY and inhibit leptin. It effectively promotes appetite for

关 键 词：小儿厌食症 针刺疗法 穴 四缝 促人生长激素释放肽 瘦素 神经肽Y 

分 类 号：R246.4[医药卫生—针灸推拿学]