巨噬细胞在创面愈合中的作用研究进展  

Advancement in the research of the role of macrophages in wound healing

作　　者：薛亮[1] 刘旭盛[1] 

机构地区：[1]中山大学附属第一医院烧伤科,广州510080

出　　处：《中华烧伤杂志》2013年第1期62-64,共3页Chinese Journal of Burns

摘　　要：创面愈合是机体面对外来损伤因素进行自我保护的病理生理过程.创面愈合过程分为炎症期、修复期和组织重塑期,这3个时期相互重叠,协调促进创面愈合.巨噬细胞是创面愈合过程中的重要细胞,其作用贯穿整个创面修复过程,不但可以吞噬清除坏死组织、病原微生物和异物,而且可以分泌多种细胞因子趋化修复细胞,刺激细胞增殖,促进血管化,加速胶原沉积和肉芽新生.Macrophages play important roles in all stages of wound healing.Changes in micro-environment leads to transformation of macrophages type Ⅰ and type Ⅱ,thereby playing a role in wound healing.During the early inflammatory phase,type Ⅰ macrophages exert pro-inflammatory function such as antigen-presenting,phagocytosis,and the production of inflammatory cytokines and growth factors.While during the wound healing phase,macrophages were transformed into type Ⅱ,which stimulate the proliferation of fibroblasts,keratinocytes,and endothelial cells by expressing growth factors.This results in the formation of granulation tissue,angiogenesis,and the formation of ECM,so as to promote wound healing.This review summarizes the function and change in phenotype of macrophages in different stages of wound healing.

关 键 词：巨噬细胞 创面修复 血管生成 

分 类 号：R641[医药卫生—外科学]