流动注射计时电流法检测甲氧氯普胺  

Determination of metoclopramide by flow injection analysis with chronoamperometry

作　　者：彭亚鸽[1] 谭颖[2] 李丛丛[2] 

机构地区：[1]宁夏大学化学化工学院,宁夏银川750021 [2]陕西师范大学化学化工学院,陕西西安710062

出　　处：《宁夏工程技术》2012年第4期341-344,共4页Ningxia Engineering Technology

基　　金：国家自然科学基金青年基金资助项目(21005003)

摘　　要：基于多壁碳纳米管修饰印刷碳电极对甲氧氯普胺的电催化作用,建立了测定甲氧氯普胺的流动注射计时电流法.与印刷碳电极相比,多壁碳纳米管修饰印刷碳电极显著降低了甲氧氯普胺的氧化峰电位,提高了氧化峰电流.测定甲氧氯普胺的线性范围为8.04×10-5～1.0×10-3mol/L,检出限为5.0×10-5mol/L(S/N=3);1.0×10-4mol/L的甲氧氯普胺测定的RSD为3.0%(n=9).方法已成功应用于药片中甲氧氯普胺含量的测定.Based on the electrocatalyst of metoclopramide （MCPM） at the the multi-walled carbon nanotubes （MWCNT） modified screen-printed carbon electrode, a novel method was proposed for determination of MCPM using flow injection analysis （FIA） coupled with chronoamperometry （CA） detection. At MWCNT modified screen-printed carbon electrode, the oxidation peak potential of MCPM decreased, and the oxidation current of MCPM greatly enhanced. Under the optimized conditions, The linear range for the determination of MCPM was 8.04×10^-5~1.0~×10^-3 mol/L with the detection limit of 5.0×10^-5 mot/L （S/N=3）. The RSD was 3.0% for 1.0×10^-4 mol/L metoclopramide （n=9）. The method has been successfully applied to the determination of MCPM in tablet.

关 键 词：甲氧氯普胺 多壁碳纳米管 流动注射 计时电流法 

分 类 号：O657.1[理学—分析化学]