何首乌致肝损伤病例分析  

Case Analysis of Liver Injury Induced by Polygoni Multiflori Radix

作　　者：谢先吉[1] 马葵芬[1] 刘莹[1] 

机构地区：[1]浙江大学医学院附属第一医院药剂科,浙江杭州310003

出　　处：《药品评价》2012年第32期36-38,共3页Drug Evaluation

基　　金："何首乌致急性肝损伤的机制研究与CYP1A2基因多态性的相关性研究"。浙江省中医药管理局基金项目;编号:2011ZA053

摘　　要：目的:分析何首乌致药物性肝损伤(DILI)的特点。方法:回顾性分析2008年3月～2012年3月我院收治的10例何首乌致肝损伤患者临床资料,对其病因、肝功能指标、影像资料、治疗方案、预后和转归进行分析。结果:10例患者经过药物治疗和人工肝技术支持,除1例出现肝性脑病自动出院,其余9例均有不同程度好转。首乌所致药物性肝损伤以肝细胞损伤型居多,混合型其次,肝内淤胆型最少。结论:何首乌所致的药物性肝损伤具有一定的剂量依赖性及时间依赖性可能;与肝脏代谢酶缺陷或功能障碍有一定的相关性。Objeclive： To study the characteristics of drug-induced liver injury （DILl） due to polygoni multiflori radix. Methods： A retrospective analysis was made on the etiology, indicators of liver function, image data, treatment options, prognosis and outcome, according to the clinical materials of 10 patients from March, 2008 to March, 2012 in our hospital. Results： After drug treatment and artificial liver support, with the exception of one case automatically discharged, nine cases had improvement with varying degrees. Most phenotype of Polygoni multiflori radix-induced liver injury was liver cell damage, the second was hybrid, and the least was intrahepatic cholestasis. Conclusions： Polygoni multiflori radix-induced liver injury may be dose-dependent and time- dependent, which maybe related with liver metabolic enzyme deficiencies or dysfunction.

关 键 词：何首乌 药物性肝损伤 

分 类 号：R595.3[医药卫生—内科学]