盐酸多西环素羧甲基壳聚糖微球的体外释放研究  被引量:2

Drug Release of Doxycycline Hydrochloride Carboxymethyl Chitosan Microspheres in vitro

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作  者:李欧[1,2] 刘祖雄[1] 胡戴[1,2] 符旭东[1] 

机构地区:[1]广州军区武汉总医院药剂科,武汉430070 [2]湖北中医药大学

出  处:《中国药师》2012年第12期1674-1678,共5页China Pharmacist

基  金:武汉市科技攻关计划(编号:201161038346)

摘  要:目的:探讨各因素对盐酸多西环素羧甲基壳聚糖微球体外释放度的影响。方法:采用乳化-交联固化法制备盐酸多西环素羧甲基壳聚糖微球(doxycycline hydrochloride-carboxymethyl chitosan-microspheres,DXY-CMCTS-MS),采用动态透析法测定体外释药性能,用紫外分光法测定盐酸多西环素浓度,绘制其释放曲线。结果:释放介质pH越大,交联剂量越大,固化时间越长,药物/载体比例越小,药物的释放则越慢。结论:该制剂制备工艺切实可行,所得DXY-CMCTS-MS具有明显的缓释效果。Objective:To discuss the influencing factors on drag release of periodontal sustained microspheres in vitro.Method: Doxycycline hydrochloride carboxymethyl chitosan microspheres(DXY-C'MC-MS) were prepared by emulsifying cross-linking process and UV spectrophotometry was used in the determination of doxycycline hydrochloride to obtain the release profile in vitro.Result:The drug release rate was reduced with the increase of pH value of the release medium,the cross-linking dosage and the curing time.Conclusion: The preparation technique is feasible,and the DXY-CMC-MS show obvious sustained release property.

关 键 词:盐酸多西环素 羧甲基壳聚糖 微球 体外释放 

分 类 号:R945[医药卫生—微生物与生化药学]

 

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