复方菊明提取物对高血压伴高尿酸血症模型大鼠尿酸的影响  

Effect of Compound Juming Extract(CJE) Extracts on Uric Acid level of Hyperuricemia Spontaneously Hypertensive Rats

作　　者：唐夏莉[1] 陈素红[2] 吕圭源[1] 苏洁[1] 佟海宁[1] 占阮娟[1] 张燕坪[1] 

机构地区：[1]浙江中医药大学,杭州310053 [2]温州医学院

出　　处：《浙江中医药大学学报》2012年第12期1321-1324,共4页Journal of Zhejiang Chinese Medical University

基　　金：国家"重大新药创制"科技重大专项(2009ZX09502-016;2011ZX09101-002-07)~~

摘　　要：[目的]观察复方菊明提取物(Compound Juming extract,CJE)对高嘌呤饲料饲喂自发性高血压大鼠(Spontaneously Hypertensive Rats,SHR)致高血压伴高尿酸血症模型大鼠的降尿酸作用,并初步探讨其作用机制。[方法]采用SHR连续饲喂高嘌呤饲料8周建立高血压伴高尿酸血症模型大鼠,在造模的同时灌胃给予CJE,连续8周。分别于给药前第0周,给药第3周、第6周、第8周取血测定血清尿酸(uric acid,UA)、肌酐(creatinine,Cr)、尿素氮(nitrogen,BUN)水平;末次给药后取血测定血清黄嘌呤氧化酶(xanthine oxidase,XOD)、腺苷脱氨酶(adenosine deaminase,ADA)活性。[结果]CJE(10.0、5.0、2.5g.kg-)1均能降低高血压伴高尿酸血症大鼠血清UA、Cr、BUN水平,降低血清XOD、ADA活性。[结论]CJE具有显著的降尿酸及改善肾功能作用,其机制可能与抑制XOD和ADA活性有关。[Objective] To observe the effect and mechanism of CJE on uric acid level in spontaneously hypertensive rats accompanied with hyperuricemia,which induced by high-purine diet.[Methods] Spontaneously hypertensive rats were continuously received high-purine diet for 8 weeks to establish hyperuricemia and hypertension model.CJE（10.0,5.0,and 2.5g·kg-1） were given once a day for 8 weeks.At0,3,6 and 8 weeks,blood sample was collected to detect levels of serum uric acid（UA）,nitrogen（BUN）,and creatinine（Cr）.After the last administration,serum was collected to detect xanthine oxidase（XOD） and adenosine deaminase（ADA） activity.[Results] All CJE（10.0g/kg,5.0g/kg,2.5g/kg）can reduce serum UA,BUN,Cr levels and serum XOD,ADA activities.[Conclusion] CJE could significantly decrease uric acid level and improve kidney function.The mechanism may be related with the inhibition of XOD and ADA activity.

关 键 词：CJE 高嘌呤饲料 尿酸 肾功能 

分 类 号：R331[医药卫生—人体生理学]