体外受精-胚胎移植术后输卵管妊娠与宫腔因素的关系  

Relationship between tubal pregnancy following in vitro fertilization and embryo transfer and uterine factors

作　　者：张莹莹[1] 樊琳琳[1] 苏迎春[1] 郭艺红[1] 孔慧娟[1] 

机构地区：[1]郑州大学第一附属医院生殖医学中心,郑州450052

出　　处：《郑州大学学报（医学版）》2012年第6期847-849,共3页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:分析辅助生殖技术后发生输卵管妊娠(TP)的危险因素。方法:回顾性分析郑州大学第一附属医院生殖医学中心行常规体外受精-胚胎移植(IVF-ET)、卵胞质内单精子显微注射-胚胎移植(ICSI-ET)、冻融胚胎移植(FET)后发生TP的70例患者(病例组),随机抽取同期宫内妊娠患者210例为对照组。结果:共行辅助生殖技术助孕4474个周期(3985例),临床妊娠2181个周期,其中异位妊娠(EP)83个周期(3.81%),包括TP70个周期(3.21%),宫内外同时妊娠13个周期(0.60%)。70例TP中51例(72.86%,χ2=5.453,P=0.020)有输卵管及或盆腔病变,18例(25.71%,χ2=6.434,P=0.011)存在宫腔环境不良。结论:宫腔粘连、子宫内膜炎、子宫内膜息肉、瘢痕子宫等不良宫腔环境是辅助生殖技术后TP的危险因素。Aim：To investigate the risk factors of tubal pregnancies after assisted reproductive technology.Methods：The clinical data of tubal pregnancies after in vitro fertilization and embryo transfer and intracytoplasmic sperm injection and embryo transfer and frozen-thawing embryo transfer were retrospectively analyzed.A total of 70 cases of tubal pregnancy were collected as study group,and 210 cases of normal pregnancy were chosen as control group.Results：A total of 4 474 cycles（3 985 cases） had received the assisted reproductive technology treatment,and 2 181 cycles achieved clinical pregnancies,out of which,83 were ectopic pregnancies,and 70（3.21%） were tubal pregnancies,13（0.60%） were intrauterine and extrauterine pregnancy.Among tubal pregnancies,51 cases（72.86%,χ2=5.453,P=0.020） had fallopian tube and pelvic lesions,18 cases（25.71%,χ2=6.434,P=0.011） had abnormal uterine environment.Conclusion：Poor uterine environment such as intrauterine adhesion,endometritis,endometrial polyp,and scarred uterus are the risk factors of tubal pregnancy following assisted reproductive technology.

关 键 词：输卵管妊娠 体外受精-胚胎移植 子宫内膜 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学]