耐甲氧西林金黃色葡萄球菌耐药性分析  

Resistance and Gene Type of Methicillin Resistant Staphylococcus Aureus

作　　者：管婧 卓超 李红玉[2] 

机构地区：[1]呼吸疾病国家重点实验室,广东广州510120 [2]中山大学附属第二医院检验科,广东广州510120

出　　处：《今日药学》2012年第12期716-719,共4页Pharmacy Today

基　　金：广东省科技厅重点攻关项目资助课题(编号:2009A030301011)

摘　　要：目的了解耐甲氧西林金黄色葡萄球菌(MRSA)的耐药性情况,为临床合理选用抗生素提供参考和依据。方法参照2009年临床实验室标准化研究所(CLSI)标准,对广东某综合三甲医院2003年1月～2009年6月各种临床标本中分离的188株MRSA,用K-B法对10种抗菌素进行的敏感性检测;微量稀释法对万古霉素、利奈唑烷的敏感性进行检测,统计MIC均值。结果 188株MRSA利奈唑烷、替考拉宁、万古霉素对敏感率均为100.0%,对利奈唑烷和万古霉素的MIC几何均值分别为0.919μg/ml和1.322μg/ml。对氯霉素、利福平的敏感率为71.8%及70.7%,其他被检测的抗菌素的敏感率均低于50.0%。结论 MRSA对利奈唑烷、替考拉宁、万古霉素敏感性高,而对临床常用的其它抗菌药物呈多重耐药性。Objective To study the resistance of methicillin-resistant Staphylococcus aureus（MRSA）,so as to provide the epidemiology basis for selection of antibiotics in clinic.Methods A total of 188 strains were isolated from one teaching hospital in Guangdong from 2003 to 2009.The antibiotic susceptibility test including K-B disk diffusion method and micro-dilution,and MIC50,MIC90 and geometric-mean-MIC of vancomycin and linezolid were calculated.Results All isolates were susceptible to vancomycin,linezolid and teicoplanin,and the geometric-mean-MIC was 1.322 μg/ml in vancomycin,0.919 μg/ml in linezolid,while the sensitivity rate of chloramphenicol,rifampicin were 71.8% and 70.7%,respectively,other antibiotic sensitivity were less than 50.0%.Conclusions MRSA have a higher sensitivity of linezolid,teicoplanin,vancomycin,showed multi-drug resistant to the clinical commonly used antibiotics.

关 键 词：耐甲氧西林金黄色葡萄球菌 耐药性 

分 类 号：R969[医药卫生—药理学]