体质量指数与左心室舒张功能不全的关系  

Relations between body mass index and left ventricular diastolic dysfunction

作　　者：林岫芳[1] 王成山[1] 谭文亮[1] 危小良[1] 阮芸[1] 

机构地区：[1]中山大学附属第五医院心内科,519000

出　　处：《新医学》2012年第12期845-849,共5页Journal of New Medicine

基　　金：中山市科技局(2009-RT-126)

摘　　要：目的:研究体质量指数异常与左心室舒张功能不全的关系。方法:收集行心脏超声检查且资料较完整的患者297人,按BMI水平,分为体质量正常组(119例)、超重组(94例)、肥胖组(84例)3组;探讨BMI各组与左心室舒张功能各项指标的相关性。结果:超重组的E/A平均值较正常组的E/A平均值低(Z=-0.243,P<0.001),肥胖组的E/A平均值较正常组的E/A平均值低(Z=-0.429,P<0.001),肥胖组的E/A平均值较超重组的E/A平均值低(Z=-0.186,P<0.001),各组间比较时P<0.001,统计学上有意义。左心室质量指数(LVWI)与BMI呈线性正相关,LVWI随着BMI升高而增大;E/A与BMI呈线性负相关,E/A值随着BMI增加渐渐降低。Logistic回归分析表明:年龄、性别、BMI、LVWI与左心室舒张功能不全相关;BMI越高,左心室舒张功能不全的风险越大;BMI对E/A的影响最大,其次为LVWI。高血压组E/A平均值比正常血压组低0.085,P<0.01,高血压是影响E/A值的因素。结论:BMI与左心室舒张功能不全具有独立相关性;随着BMI的升高,左心室舒张功能不全发生率增加。Objective： To analyze the relationship between the abnormal body mass index and left ventricular diastolic dysfunction. Methods： Collection of cardiac ultrasound examination and the information more complete with 297 patients, according to the level of BMI, patients were divided into three groups ： the normal weight group （119 cases） , overweight （94 cases） , the obese group （n =84）, BMI groups and left ventricular diastolic func- tion indexes correlation, were enrolled. Results： The mean E/A of overweight group were lower than the normal group, （Z= -0.243, P〈0.001）; - 0. 429, P 〈 0. 001 ）, the mean E/A the mean E/A of obese group of obese group were lower than were lower than the normal group, （Z = the overweight group, （Z = -0. 186, P 〈0. 001 ）o （all compares between the two groups were statistically meaningful, P 〈 0. 001 ）. LVW! with BMI was positively related, left ventricular mass index increased as BMI increased; the E/A was negatively correlated with BMI, as the BMI increased, E/A gradually reduced. In the logistic regression analysis, the results showed that： age, gender, body mass index, left ventricular mass index was associated with left ventricular diastolic dysfunction; the higher the body mass index, the greater risk of left ventricular diastolic dysfunction. The BMI were the largest risk factor to the E/A, followed by LVWI. Hypertension group had lower E/A than normal blood pressure group （0. 085, P 〈 0. 01 ）. Hypertension was a influenced factor of the left ventricular diastolic dysfunction. Conclu- sions： BMI is independently associated with left ventricular diastolic dysfunction. As the BMI increased, the inci- dence of left ventricular diastolic dysfunction was increased.

关 键 词：体质量指数 肥胖 左心室重构 E A值 左心室舒张功能不全 

分 类 号：R541.6[医药卫生—心血管疾病]