急性冠脉综合征患者血清TNF受体-配体家族高表达的临床意义  

The clinical significance of increased serum TNF receptor-ligand family in patients with acute coronary syndrome

作　　者：严金川[1] 王翠平[1] 臧璇[1] 徐良洁[1] 袁伟[1] 

机构地区：[1]江苏大学附属医院心脏病科,212001

出　　处：《江苏医药》2013年第2期163-165,共3页Jiangsu Medical Journal

基　　金：江苏省科教兴卫工程(LJ201116);镇江市社会发展项目资助(SH2010012)

摘　　要：目的探讨急性冠脉综合征(ACS)患者血清可溶性肿瘤坏死因子(TNF)受体-配体家族CD40L、OX40L及CD137水平变化的临床意义。方法 ELISA法检测稳定型心绞痛组(SA组,50例)、不稳定心绞痛组(UA组,50例)、急性心肌梗死组(AMI组,80例)患者和正常对照组(C组,40例)的血清可溶性CD40L、OX40L及CD137水平。结果 UA组血清CD40L为(18.6±4.7)ng/ml,OX40L为(22.5±4.3)ng/ml,CD137为(27.8±7.1)ng/ml;AMI组血清CD40L为(20.7±5.2)ng/ml,OX40L为(24.2±4.6)ng/ml,CD137为(30.2±6.5)ng/ml。两组上述三项指标均明显高于SA组的(6.6±2.1)ng/ml、(9.5±2.5)ng/ml和(7.2±2.3)ng/ml和C组的(7.0±2.2)ng/ml、(9.1±2.4)ng/ml和(7.3±2.4)ng/ml(P<0.05)。ACS患者血清CD40L、OX40L及CD137水平与心肌肌钙蛋白I(cTnI)水平及冠脉复杂狭窄显著相关。结论血清CD40L、OX40L及CD137水平升高是冠脉斑块不稳定的活动性标志物。Objective To investigate the clinical significance of serum soluble TNF receptor-ligand family CD40L,OX40L and CD137 levels in the patients with acute coronary syndrome（ACS）. Methods Serum levels of soluble CD40L,OX40L and CD137 were determined with ELISA in the patients with stable angina（group SA,50 cases）,unstable angina（group UA,50 cases）,acute myocardial infarction（group AMI,80 cases） and healthy controls（group C,40 cases）. Results The serum CD40L,OX40L and CD137 were（18.6±4.7）ng/ml,（22.5±4.3）ng/ml and（27.8±7.1）ng/ml in group UA and（20.7±5.2）ng/ml,（24.2±4.6）ng/ml and（30.2±6.5）ng/ml in group AMI,which were all significantly higher than（6.6±2.1）ng/ml,（9.5±2.5）ng/ml and（7.2±2.3）ng/ml in group SA and （7.0±2.2）ng/ml,（9.1±2.4）ng/ml and（7.3±2.4）ng/ml in group C （P〈0.05）.An obvious correlation was observed between serum soluble CD40L,OX40L, CD137 levels and cTnI and complex coronary stenoses. Conclusion The increased expressions of serum CD40L,OX40L and CD137 may be the markers for unstable plaque and activity of coronary diseases.

关 键 词：急性冠脉综合征 CD40 OX40 CD137 

分 类 号：R541[医药卫生—心血管疾病]