急性毛细支气管炎患儿血清sVCAM-1、CK-MB变化  

Changes of serum sVCAM-1 and CK-MB in children with acute bronchiolitis

作　　者：龚红蕾[1] 徐美玉[1] 石明明[1] 吴惠芳[1] 孙宝兰[1] 蒋晓天[1] 郭晓理[1] 

机构地区：[1]南通大学附属医院儿科,江苏省226000

出　　处：《江苏医药》2013年第2期171-173,共3页Jiangsu Medical Journal

摘　　要：目的探讨急性毛细支气管炎患儿血清可溶性血管细胞黏附分子1(sVCAM-1)和肌酸磷酸激酶(CK-MB)的变化以及其与病情的关系。方法选择急性毛细支气管炎急性期患儿40例(A组,重症型8例,普通型32例)、缓解期30例(B组)和同期健康体检儿童20例(C组),用ELISA法检测sVCAM-1,ACCESS法检测CK-MB。结果 A组sVCAM-1高于B组和C组[(731.22±122.10)ng/ml vs.(486.77±39.83)ng/ml和(465.85±33.64)ng/ml](P<0.05);A组CK-MB高于B组和C组[(5.672±8.03)μg/L vs.(2.88±1.75)μg/L和(2.62±0.85)μg/L](P<0.05)。结论急性毛细支气管炎患儿存在免疫功能的失调,sVCAM-1和CK-MB与疾病的严重程度有一定关系。Objective To investigate the changes and clinical significance of serum soluble vascular cell adhesion molecule-1（sVCAM-1） and creatine phosphokinase（CK-MB） in children with acute bronchiolitis. Methods With ELISA and ACCESS methods,serum sVCAM-1 and CK-MB were detected in 40 children with acute bronchiolitis（group A）,30 cases with bronchiolitis in remission stage（group B） and 20 normal children（group C）. Results Serum level of sVCAM-1 of group A was higher than that of group B and group C[（731.22±122.10）ng/ml vs.（486.77±39.83）ng/ml and（465.85±33.64） ng/ml]（P〈0.05）.So did that of CK-MB[（5.672±8.03）μg/L vs.（2.88±1.75）μg/L and（2.62±0.85）μg/L]（P〈0.05）. Conclusion Children with acute bronchitis have immune disorders.Serum levels of sVCAM-1 and CK-MB have a certain relationship with the severity of the disease.

关 键 词：可溶性血管细胞黏附分子1 肌酸磷酸激酶 急性毛细支气管炎 

分 类 号：R725[医药卫生—儿科]