三氧化二砷治疗儿童急性早幼粒细胞白血病心脏毒性的临床观察  

Clinical study of cardiac toxicity in children with acute promyelocytic leukemia treated by arsenic trioxide

作　　者：孙伊娜[1] 柴忆欢[1] 胡绍燕[1] 何海龙[1] 王易[1] 赵文理[1] 李捷[1] 李建琴[1] 卢俊[1] 肖佩芳[1] 

机构地区：[1]苏州大学附属儿童医院血液科,江苏省215003

出　　处：《江苏医药》2013年第2期197-199,共3页Jiangsu Medical Journal

摘　　要：目的观察三氧化二砷(As2O3)对儿童急性早幼粒细胞白血病(APL)的心脏毒性。方法 11例儿童APL共进行18例次As2O3治疗,观察治疗前后心脏症状及体征、心电图、心脏彩色多普勒超声、心肌酶、心肌钙蛋白变化。结果As2O3治疗后,异常心脏症状及体征发生率为11.1%,心率加快发生率为27.8%,心电图异常发生率为44.4%,心脏多普勒超声异常发生率为11.1%,心肌钙蛋白异常发生率为5.6%。心脏毒性无性别和年龄(<10岁vs.>10岁)差异。结论常规剂量As2O3治疗儿童APL时心脏毒性较轻。Objective To study the cardiac toxicity of arsenic trioxide（As2O3） in children with acute promyelocytic leukemia（APL）. Methods Eleven APL children received totally 18 courses of As2O3 treatment.The cardiac symptoms and signs,changes of ECG,Doppler echocardiography and myocardial enzyme levels were observed before and after As2O3 treatment. Results After treatment,the incidence rate of abnormal cardiac symptoms and signs was 11.1%,that of heart rate acceleration was 27.8%,that of abnormal ECG was 44.4%,and that of abnormal Doppler echocardiogram was 11.1%.The increased cTnI occurred in 5.6%.The changes above had no significant difference between male and female or between aged less than 10 years old and that more than 10 years old. Conclusion Treatment with conventional dose of As2O3 is safe without severe cardiac toxicity in treating APL children.

关 键 词：急性早幼粒细胞白血病 三氧化二砷 心脏毒性 儿童 

分 类 号：R725[医药卫生—儿科]