PcG蛋白复合体对Hox基因的调节  

PcG Protein Complex in the Regulation of Hox Genes

作　　者：季思涵[1] 管祎祺[1] 吴向伟[1] 薛丽香[1] 

机构地区：[1]北京大学医学部生物化学与分子生物学系,北京100191

出　　处：《中国生物化学与分子生物学报》2013年第2期117-121,共5页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金项目(No.31071206);国家基础科学人才培养基金(No.J1030831/J0108)~~

摘　　要：PcG蛋白广泛参与到生长、发育、增殖、分化以及肿瘤发生等重要过程.而目前为止对PcG蛋白的靶基因研究最透彻的就是Hox家族.Hox基因存在于一个高度保守的基因簇内,在调控维持正常发育及肿瘤发生中有重要作用.一般认为,PcG蛋白复合物对Hox基因进行以组蛋白表观修饰为主的沉默作用,指导Hox基因适时适地发挥功能.同时,这个过程还需要DNA连接蛋白、ncRNA等分子的辅助.本文对Hox基因和PcG蛋白的组成和功能进行介绍,并重点归纳总结了对二者关系的经典和最新认识.PcG proteins are extensively involved in the growth, development, prohieratlon, differentiation and tumorigenesis. Hox family is by far one of the most well-known PcG protein target genes. Hox is organized in a highly conserved gene cluster. Hox plays a key role in the regulation and maintenance of normal development and tumorigenesis. It is generally believed that PcG complexes silence Hox gene through epigenetic modification of histones, and results in appropriate temporal control of Hox expression. Such process requires the DNA ligation factors and ncRNA. In this review, we introduced the structure and function of Hox genes and PcG proteins. We also summarized both classic and up-to-date knowledge of the Hox and PcG.

关 键 词：PCG蛋白 Hox家族 表观遗传调控 

分 类 号：Q71[生物学—分子生物学]