能谱CT评估颈动脉粥样硬化非钙化斑块成分  

Spectral CT imaging for the assessment of non-calcified plaque compositions in carotid atherosclerosis

作　　者：任小璐[1] 刘云[1] 王杏娟[2] 王雪梅[2] 张志远[1] 宝金瑞[1] 

机构地区：[1]宁夏医科大学附属心脑血管病医院放射科,宁夏银川750001 [2]宁夏医科大学临床医学院,宁夏银川750001

出　　处：《中国医学影像技术》2013年第2期202-205,共4页Chinese Journal of Medical Imaging Technology

摘　　要：目的应用能谱CT研究颈动脉粥样硬化(AS)非钙化斑块成分及稳定性。方法收集35例颈动脉狭窄患者,行颈动脉能谱CTA检查,应用能谱分析软件,分析非钙化斑块成分,对不同成分的能谱CT特征性参数进行独立样本t检验。结果 35例共检出非钙化斑块65处,其中脂质成分23处,纤维成分33处,血栓样组织9处。脂肪成分、纤维成分、血栓样组织的CT值衰减曲线斜率分别为-3.46±0.62、2.06±0.73、0.32±0.09;有效原子序数分别为3.73±0.88、8.76±0.53、7.60±0.78;碘(脂肪)浓度分别为(-2.62±0.83)g/L、(3.65±0.56)g/L、(1.71±0.74)g/L,差异均有统计学意义(P均<0.05)。结论颈动脉非钙化斑块中的脂质成分、纤维成分及血栓样组织表现出不同的能谱成像特性;能谱CT参数分析可为区分非钙化斑块成分提供量化依据。Objective To assess the compositions and stability of non-calcified plaques in patients with carotid atherosclerosis by dual energy spectral CT. Methods Thirty-five patients with carotid artery stenosis underwent CTA by dual energy spectral CT. Using gemstone spectral imaging （GSI） viewer, the compositions of non-calcified plaques were analyzed, and CT spectral imaging parameters were evaluated statistically by using independent-samples t test. Results Totally 65 non-calcified plaques were found in 35 patients, including 23 lipid plaques, 33 fiber plaques and 9 thrombotic tissue. The slope of spectral curve was -3.46±0.62, 2.06±0.73 and 0.32±0.09, effective-Z values was 3.73±0.88, 8.76±0.53, 7.60±0.78, and iodine contents was （-2.62±0.83）g/L, （3.65±0.56）g/L, （1.71±0.74）g/L for lipid plaques, fiber plaques and thrombotic tissue, respectively. There were statistical differences between any two kinds of plaques （all P〈0.05）. Conclusion Lipid compositions, fiber components and thrombotic tissue in non-calcified plaque have distinctive spectral imaging characteristics. The parameters of CT spectral imaging can provide quantification information for differentiation of lipid, fiber and thrombus plaques.

关 键 词：体层摄影术 X线计算机 颈动脉 动脉粥样硬化 非钙化斑块 

分 类 号：R814.42[医药卫生—影像医学与核医学] R543[医药卫生—放射医学]