贵屿地区学龄前儿童铅、镉暴露对固有免疫细胞的影响  

Effect of Lead and Cadmium Exposure on the Levels of Innate Immune Cells in Preschool Children

作　　者：孙迪[1] 张健[1] 黄彬亮[1] 张浴玲[1] 徐锡金[1] 霍霞[1] 

机构地区：[1]汕头大学医学院分析细胞实验室,广东汕头515041

出　　处：《汕头大学医学院学报》2012年第4期193-195,共3页Journal of Shantou University Medical College

基　　金：国家自然科学基金资助项目(21177080);广东省自然科学基金资助项目(S2011020002399)

摘　　要：目的:探讨铅、镉暴露对学龄前儿童固有免疫细胞的影响。方法:采集静脉血样本(237例。暴露组(114例)来自贵屿当地幼儿园,对照组(123例)来自濠江区幼儿园)检测儿童静脉血中铅、镉及固有免疫细胞的浓度。结果:暴露组血铅(中位数9.6μg/dL)、镉(中位数2.3μg/L)水平显著高于对照组(7.8μg/dL、1.7μg/L)(P<0.001)。暴露组与对照组比,嗜酸性粒细胞,中性粒细胞,NK细胞有统计学意义(P<0.001,P<0.001,P<0.05),而单核细胞和嗜碱性粒细胞无统计学意义。相关性分析显示,血镉和嗜酸性粒细胞及中性粒细胞之间存在一定正相关(P<0.05)。结论:贵屿地区铅、镉暴露可能对学龄前儿童体内的固有免疫细胞有影响。Objective：To investigate the effect of lead and cadmium exposure on the levels of innate immune cells in preschool children.Methods：Two hundred and thirty-senven preschool children（114 from Guiyu（exposure group）and 123 from Haojiang（control group））were recruited.The blood lead level,blood cadmium level and innate immune cells in blood were analyzed and compared.Results：The blood lead and cadmium levels in the exposure group（9.6 μg/dL,2.3 μg/L）were significantly higher than those in the control group（7.8 μg/dL,1.7 μg/L）（P0.001）.Significant difference was found between two groups about eosinophils,neutrophil and NK cell（P0.001,P0.001,P0.05）,but no significant diffe-rence about monocyte and basophils（P0.05）.There was a positive correlation between blood cadmium level and eosinophils,neutrophil.Conclusion：Lead and cadmium exposure may have effect on innate immune cells in preschool children.

关 键 词：血铅 血镉 固有免疫细胞 

分 类 号：X503.1[环境科学与工程—环境工程]