利塞膦酸钠致剥脱性皮炎  

Exfoliative dermatitis caused by risedronate sodium

作　　者：胡晓蕾[1] 刘锐[1] 王渝[1] 何菊英[1] 

机构地区：[1]第三军医大学西南医院药剂科,重庆400038

出　　处：《药物不良反应杂志》2012年第5期304-305,共2页Adverse Drug Reactions Journal

摘　　要：1例82岁女性患者因重度骨质疏松口服利塞膦酸钠片5 mg,1次/d。第2天患者出现全身弥漫性红斑伴瘙痒及部分红斑融合,第4天部分皮肤出现水疱破溃并有脓性分泌物。立即停用利塞膦酸钠,给予地塞米松、氢化可的松琥珀酸钠静脉滴注,盐酸左西替利嗪、富马酸酮替芬口服,氧化锌洗剂外用,同时给予抑酸、补钾等对症处理。治疗12 d后,患者全身皮疹逐渐消退。An 82-year-old woman received risedronate sodium 5 mg once daily for severe osteoporosis. On day 2, she developed diffuse red erythema involving her entire body with pruritus and partial confluent plaques. On day 4, some blisters ruptured along with purulent secretions on her partial skin. Risedronate sodium was stopped immediately, and an IV infusion of dexamethasone and an IV infusion of hydrocortisone sodium suecinate were given; levocetirizine hydrochloride and ketotifen fumarate were given by mouth; zinc oxide lotion was given for external application; and at the same time, symptomatic treatments, such as acid suppression, potassium supplement, were given. After 12 days of treatment, the patient＇s rash on her entire body gradually subsided.

关 键 词：皮炎 剥脱性 利塞膦酸钠 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]