垂体后叶素相关电解质异常  

Electrolyte abnormalities associated with pituitrin

作　　者：徐志英[1] 曹莺 

机构地区：[1]张家港市第一人民医院药剂科,215600

出　　处：《药物不良反应杂志》2012年第5期314-315,共2页Adverse Drug Reactions Journal

摘　　要：1例19岁男性肺结核患者因大咯血入院。入院当日血电解质检查示钾3.5 mmol/L、钠137 mmol/L、氯104 mmol/L。给予其甲磺酸酚妥拉明20 mg、垂体后叶素24 U分别加入0.9%氯化钠注射液50 ml中以5 ml/h速度每日持续静脉泵入,同时给予抗结核治疗(对氨基水杨酸异烟肼+左氧氟沙星+阿米卡星)。入院第5天患者出现乏力、头痛,血电解质检查示钾3.1 mmol/L、钠122 mmol/L、氯88 mmol/L、磷0.65 mmol/L。垂体后叶素减量至18 U,1次/12 h,同时补充电解质,其他药物维持不变。第6天检查示血钾2.8 mmol/L、钠117 mmol/L、氯83 mmol/L、磷0.54 mmol/L、钙1.99 mmol/L。停用垂体后叶素,补充电解质。入院第10天,患者电解质恢复正常:钾4.3 mmol/L、钠136 mmol/L、氯101 mmol/L、钙2.17 mmol/L、磷0.82 mmol/L。A 19-year-old man with tuberculosis was hospitalized due to massive hemoptysis. On the day of admission, examination of the patient showed blood electrolyte concentrations as follows： potassium 3.5 mmol/L, sodium 137 retool/L, and chlorine 104 mmol/L. Phentolamine mesilate 20 mg and pituitrin 24 U in 0.9% sodium chloride 50 ml was continuously infused at a rate of 5 ml/ h via pump every day. At the same time, he was given anti-TB treatment including isoniazid aminosalicylate, levofloxacin, and amikacin. On day 5 of admission, the patient developed weak and headache. Electrolyte tests showed the following levels ： potassium 3.1 mmol/L, sodium 122 mmol/L, chlorine 88 retool/L, phosphorus 0.65 mmol/L. Pituitrin was reduced to 18 U onee every 12 hours. Meanwhile electrolyte supplementation was given and other medications remained unchanged. On day 6, electrolyte tests revealed a potassium level of 2.8 mmol/L, a sodium level of 117 retool/L, a chlorine level of 83 mmol/L, a phosphorus level of 0.54 retool/L, and a calcium level of 1. 99 xnmol/L. Pituitrin was stopped and electrolyte supplementation was given. On day 10 of admission, laboratory tests showed the above-mentioned electrolyte levels returned to normal range as follows： potassium 4.3 mmol/L, sodium 136 mmol/L, chlorine 101 mmol/L,calcium 2.17 retool/L, and phosphorus 0.82 mmol/L.

关 键 词：垂体后叶素 水电解质失调 

分 类 号：R595.3[医药卫生—内科学]