膦甲酸钠相关急性肾衰竭  

Acute renal failure associated with foscarnet sodium

作　　者：李丹丹[1,2] 解倩[3] 王悦[3] 赵荣生[1] 

机构地区：[1]北京大学第三医院药剂科,100191 [2]北京大学药学院 [3]北京大学第三医院肾内科,100191

出　　处：《药物不良反应杂志》2012年第5期317-319,共3页Adverse Drug Reactions Journal

摘　　要：1例75岁女性患者,因带状疱疹给予膦甲酸钠3 g、1次/d静脉滴注,合并应用甲钴胺、维生素B1和新癀片、阿昔洛韦软膏。第4天,患者四肢及面部出现水肿,伴恶心、食欲不振、皮肤瘙痒。第10天,除阿昔洛韦软膏外,上述药物均停用。第12天实验室检查:血清肌酐142μmol/L,尿素氮8.6 mmol/L;尿比重1.010。考虑为急性肾衰竭、急性间质性肾炎。限制液体入量,给予低盐、低脂、优质蛋白饮食。5 d后患者水肿消退,瘙痒消失。实验室复查:血清肌酐86μmol/L,尿素氮7.4 mmol/L,磷0.9 mmol/L。A 75-year-old woman received IV infusion of foscarnet sodium 3 g once daily combined with mecobalamin, vitamin B1 , Xinhuang tablets （新癀片）, and acielovir ointment for herpes zoster. On day 4, she developed extremity and facial edema accompanied with nausea, anorexia and skin pruritus. On day 10, above-mentioned drugs were stopped except aciclovir ointment. On day 12, laboratory tests showed the following levels： serum creatinine 142 μmol/L, blood urea nitrogen 8.6 mmol/L, urine specific gravity 1. 010. Acute renal failure and acute interstitial nephritis was considered. The woman＇s fluid intake was restricted, and she received a low-salt, low-fat, and a high-protein diet. Five days later, her edema subsided and pruritus disappeared. Laboratory tests showed the following results： serum creatinine 86 μmol/L, blood urea nitrogen 7.4 retool/L, phosphorus 0.9 mmol/L.

关 键 词：肾衰竭 疱疹 带状 膦甲酸钠 

分 类 号：R595.3[医药卫生—内科学]