Gold-Catalyzed Direct Indolation of Tetrahydroisoquinolines  

作　　者：Zhang Yan Luo Sha Feng Bainian Zhu Chengjian 

机构地区：[1]School of Medicine and Pharmaceutics, Jiangnan University, Wuxi, diangsu 214122, China [2]State Key Laboratry of Coordination Chemistrry, School of Chemistry and Chemical Engi,eering, Nanjing University, Nanjing, Jiangsu 210093, China

出　　处：《Chinese Journal of Chemistry》2012年第12期2741-2746,共6页中国化学（英文版）

摘　　要：Nitrogen-containing heterocyclic compounds are important motifs of pharmaceuticals and functional materials, and there has been a growing interest in new synthetic methods for their preparations. In this paper, we report a direct cross-coupling reaction of indole with N-aryl tetrahydroisoquinolines in the presence of gold catalyst. The reaction is compatible with a wide range of substituted indoles, to enable the tbrmation of various alkylated heteroarenest, nder very mild reaction conditions.Nitrogen-containing heterocyclic compounds are important motifs of pharmaceuticals and functional materials, and there has been a growing interest in new synthetic methods for their preparations. In this paper, we report a direct cross-coupling reaction of indole with N-aryl tetrahydroisoquinolines in the presence of gold catalyst. The reaction is compatible with a wide range of substituted indoles, to enable the tbrmation of various alkylated heteroarenest, nder very mild reaction conditions.

关 键 词：C-H activation sp3 bonds indolation GOLD heterocyclic compounds 

分 类 号：O753.2[理学—晶体学] TQ463.54[化学工程—制药化工]