新疆肺结核患者耐药情况分析  

Analysis of tuberculosis drug resistance in Xinjiang

作　　者：李月华[1,2] 刘继文[1] 王新旗[2] 顾晓明[2] 吴卫东[2] 

机构地区：[1]新疆医科大学 [2]新疆维吾尔自治区疾病预防控制中心,乌鲁木齐市830000

出　　处：《疾病预防控制通报》2012年第6期17-20,共4页Bulletin of Disease Control & Prevention(China)

摘　　要：目的了解新疆维吾尔自治区肺结核患者的耐药状况。方法采用多阶段分层整群等比例随机抽样方法,对15岁及以上常住人口进行结核病可疑症状调查并拍摄胸片,所有胸部X线摄片检查异常者和肺结核可疑症状者进行3次痰涂片和2次痰培养检查,对所分离的菌株进行菌种鉴定以及7种抗结核药品的药物敏感性试验。结果菌阳患者的耐药率为36.0%,初治患者为33.3%;复治患者为50.0%;耐药率:男性为43.4%,女性24.2%;<30岁年龄组26.7%,30～60岁组46.9%,≥60岁组30.8%;南疆地区35.7%,北疆和东疆地区分别为27.3%和60.0%;在检测的7种抗结核药品中,结核分枝杆菌分离株总的耐药率顺位依次为:SM、INH、RFP、EMB和KM。结论新疆结核病耐药水平不容乐观,要加强结核病耐药水平动态监测,为制定防治措施提供理论依据。Objective To understand the status of tuberculosis drug resistance in Xinjiang. Methods With a multi-stage stratified cluster random sampling method, resident population aged 15 and above were carried out symptom survey and chest radiograph. People with abnormal chest X-ray and suspicious tuberculosis symptoms were taken 3 times of sputum smear and 2 times of sputum culture test. All isolated strains were identified and made drug susceptibility testing of seven kinds of anti-TB drugs. Results Resistant rate was 36% of patients with positive bacteria, and 33.3% of initial patients, 50% of patients in the retreatment. It was 43.4% for the male and 24.2% for the female, 26.7% for the age group less than 30 years old, 46.9% for the age group at 30 to 60-year-old, 30.8% for the age group above 60-year-old. It was 35.7% in southern Xinjiang, 27.3% in northern Xinjiang, and 60% in eastern Xinjiang. Out of the seven kinds of anti-TB drugs, the order of to- tal resistance rates of the isolated mycobacterium tuberculosis was SM, INH, RFP, EMB, and KM. Conclusions The level of resistance is worrisome. Dynamie monitoring of TB drug resistance level should be reinforced to provide a theoretieal ba- sis for formulation of prevention and control measures.

关 键 词：结核病 耐药性 调查 新疆 

分 类 号：R521[医药卫生—内科学]